{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T20:00:21Z","timestamp":1760385621303,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["NMP4\u2010SL\u20102009\u2010229244"],"award-info":[{"award-number":["NMP4\u2010SL\u20102009\u2010229244"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Membrane\u2013nanoparticle interactions are important in determining the effects of manufactured nanomaterials on cell physiology and pathology. Here, silica, titanium, zinc, and magnesium oxide nanoparticles are screened against human hERG (K<jats:sub>v<\/jats:sub>11.1) voltage\u2010gated potassium channels under a whole\u2010cell voltage clamp. 10 \u00b5g mL<jats:sup>\u22121<\/jats:sup> ZnO uniquely increases the amplitude of the steady\u2010state current, decreases the rate of hERG current inactivation during steady\u2010state depolarization, accelerates channel deactivation during resurgent tail currents, and shows no significant alteration of current activation rate or voltage dependence. In contrast, ZnCl<jats:sub>2<\/jats:sub> causes increased current suppression with increasing concentration and fails to replicate the nanoparticle effect on decreasing inactivation. The results show a novel class of nanoparticle\u2013biomembrane interaction involving channel gating rather than channel block, and have implications for the use of nanoparticles in biomedicine, drug delivery applications, and nanotoxicology.<\/jats:p>","DOI":"10.1002\/smll.201703403","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T08:23:11Z","timestamp":1519633391000},"source":"Crossref","is-referenced-by-count":10,"title":["Zinc Oxide Nanoparticles and Voltage\u2010Gated Human K<sub>v<\/sub>11.1 Potassium Channels Interact through a Novel Mechanism"],"prefix":"10.1002","volume":"14","author":[{"given":"Stefania","family":"Piscopo","sequence":"first","affiliation":[{"name":"Stazione Zoologica Anton Dohrn  Villa Comunale 80121 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5995-834X","authenticated-orcid":false,"given":"Euan R.","family":"Brown","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry Biophysics and Bioengineering William Perkin Building School of Engineering and Physical Sciences Heriot Watt University  Edinburgh EH14 4AS UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2442"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.04.021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2004.09.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp9033936"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807296105"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl080080l"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220143110"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.12.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.08.005"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl047996m"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2011.58"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2552"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90340-2"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.048"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00036.2011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja910675v"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl060860z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn3036304"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)76889-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/20\/45\/455101"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.01.008"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2010.12.069"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.03.015"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934520600966177"},{"volume-title":"Single\u2010Channel Recording","year":"2009","author":"Sakmann B.","key":"e_1_2_8_25_1"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/la203568n"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2013.05.010"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107527"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00462.2009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/047002142X.ch5","volume":"266","author":"Piper D. R.","year":"2005","journal-title":"Novartis Found. Symp."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2122519"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5092"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/379833a0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270095"},{"key":"e_1_2_8_35_1","first-page":"511","volume":"3","author":"Herzberg I. M.","year":"1998","journal-title":"J. Physiol."},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04710"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00462.2009"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0038-1098(79)90754-3"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx4004243"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp301671b"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(97)80032-6"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0361317"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6816(93)90013-L"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1151-2916.2003.tb03600.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(77)80629-7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108332"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524013666131111130058"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja107583h"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161206777585102"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.2203\/dose-response.10-002.Siddique"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsmll.201703403","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.201703403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T21:22:52Z","timestamp":1724361772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.201703403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":50,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/smll.201703403"],"URL":"https:\/\/doi.org\/10.1002\/smll.201703403","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"type":"print","value":"1613-6810"},{"type":"electronic","value":"1613-6829"}],"subject":[],"published":{"date-parts":[[2018,2,26]]},"article-number":"1703403"}}