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Here, a spray\u2010assisted coil\u2013globule transition method for encapsulating CsPbBr<jats:sub>3<\/jats:sub> (CPB) PQDs into poly(methyl methacrylate) (PMMA) polymer nanospheres is reported. Polyvinylpyrrolidone\u2010capped CPB PQDs are synthesized via the ligand assisted reprecipitation method in dichloromethane. After dissolving PMMA, the above precursor solution is sprayed into petroleum ether under high pressure N<jats:sub>2<\/jats:sub>. High\u2010pressure nebulization restricts the interactions between PMMA polymer chains, resulting in the formation of \u2248112 nm nanoscale composite spheres after a coil\u2013globule transition. The CPB@PMMA nanospheres not only possess 73% quantum yields but retain 81% of fluorescence intensity after the exposure to water for over 80 days. Due to their confined size and biocompatible encapsulation, they are readily available for cellular uptake and exhibit no toxicity on live HeLa cells. Furthermore, the PMMA surface allows for functional surface modification, carrying the possibility of targeting specific biological species and processes.<\/jats:p>","DOI":"10.1002\/smll.201803156","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T18:19:29Z","timestamp":1542392369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["Spray\u2010Assisted Coil\u2013Globule Transition for Scalable Preparation of Water\u2010Resistant CsPbBr<sub>3<\/sub>@PMMA Perovskite Nanospheres with Application in Live Cell Imaging"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuanwei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for Ultrafine Materials of Ministry of Education East China University of Science and Technology  Shanghai 200237 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