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Herein, the concept of DNA complementary base pairing rules in biology is used to design and prepare a photothermal\u2010triggered drug release system. Adenine (A) modified polydopamine nanoparticles (A\u2010PDA, photothermal reagent) can effectively bind with thymine (T) modified Zinc phthalocyanine (T\u2010ZnPc, photosensitizer) forming A\u2010PDA = T\u2010ZnPc (PATP) complex based on A = T complementary base pairing rules. Similar to DNA, whose base pairing in double strands will break by heating, T\u2010ZnPc can be effectively released from A\u2010PDA after near infrared irradiation\u2013triggered light\u2010thermal conversion to obtain satisfactory photodynamic\u2013photothermal synergistic tumor treatment. In addition, PDA can carry abundant Gd<jats:sup>3+<\/jats:sup> to provide magnetic resonance imaging guided delivery and theranostic function.<\/jats:p>","DOI":"10.1002\/smll.201803926","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T07:34:50Z","timestamp":1543476890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Drug\u2010Controlled Release Based on Complementary Base Pairing Rules for Photodynamic\u2013Photothermal Synergistic Tumor Treatment"],"prefix":"10.1002","volume":"15","author":[{"given":"Qichen","family":"Zhan","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science Jiangsu Key Laboratory of Biofunctional Materials Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Key Laboratory of Applied Photochemistry Nanjing Normal University  Nanjing Jiangsu 210023 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