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Here, a liposomal formulation of dichloroacetic acid (DCA) and metal\u2013organic framework (MOF)\u2010Fe<jats:sup>2+<\/jats:sup> (MD@Lip) has been developed, which can efficiently stimulate ROS\u2010mediated cancer cell apoptosis in vitro and in vivo. MD@Lip can not only improve aqueous solubility of octahedral MOF\u2010Fe<jats:sup>2+<\/jats:sup>, but also generate an acidic microenvironment to activate a MOF\u2010Fe<jats:sup>2+<\/jats:sup>\u2010based Fenton reaction. Importantly, MD@Lip promotes DCA\u2010mediated mitochondrial aerobic oxidation to increase intracellular hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>), which can be consequently converted to highly cytotoxic hydroxyl radicals (\u2022OH) via MOF\u2010Fe<jats:sup>2+<\/jats:sup>, leading to amplification of cancer cell apoptosis. Particularly, MD@Lip can selectively accumulate in tumors, and efficiently inhibit tumor growth with minimal systemic adverse effects. Therefore, liposome\u2010based combination therapy of DCA and MOF\u2010Fe<jats:sup>2+<\/jats:sup> provides a promising oxidative stress\u2013associated antitumor strategy for the management of malignant tumors.<\/jats:p>","DOI":"10.1002\/smll.201901156","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T06:48:48Z","timestamp":1557470928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Synergistic Amplification of Oxidative Stress\u2013Mediated Antitumor Activity via Liposomal Dichloroacetic Acid and MOF\u2010Fe<sup>2+<\/sup>"],"prefix":"10.1002","volume":"15","author":[{"given":"Lei","family":"Sun","sequence":"first","affiliation":[{"name":"National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University  Nanjing 210093 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