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This study demonstrates that biocompatible fluorescent silicon\u2010containing nanodots can be a multifunctional platform for simultaneously imaging and eliminating MRB and their biofilms. Ultrasmall epoxy group (oxirane)\u2010functionalized organosilica nanodots (OSiNDs) with a high photoluminescence quantum yield of \u224831% are synthesized via a simple one\u2010step hydrothermal treatment of an epoxy group\u2010containing silane molecule, 3\u2010glycidoxypropyltrimethoxysilane, and an organic dye, rose bengal. The resultant OSiNDs can be employed as a universal imaging reagent for visualizing various bacteria\/biofilms, including MRB and their biofilms. Moreover, the epoxy group\u2010terminated OSiNDs can be conjugated with amine\u2010containing reagents only via the simple stirring of the mixtures at an elevated temperature (e.g., 60 \u00b0C) for several hours (e.g., 3 h) without the addition of activating reagents. The amine\u2010containing antibiotic vancomycin (Van) can thus be easily conjugated with the OSiNDs, and the obtained OSiNDs\u2010Van can successfully inhibit the growth of MRB and even eliminate their biofilms. Collectively, the present work may give new impetus to the development of novel antibacterial and anti\u2010biofilm agents for overcoming the drug resistance of bacteria.<\/jats:p>","DOI":"10.1002\/smll.201901647","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T06:04:14Z","timestamp":1564380254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["One\u2010Step Synthesis of Epoxy Group\u2010Terminated Organosilica Nanodots: A Versatile Nanoplatform for Imaging and Eliminating Multidrug\u2010Resistant Bacteria and Their Biofilms"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaokai","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengming","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-2868","authenticated-orcid":false,"given":"Fu\u2010Gen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  Nanjing 210096 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,28]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn100932t"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707069"},{"key":"e_1_2_7_1_3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201206911"},{"key":"e_1_2_7_1_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.045"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b01368"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3380"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja305644e"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201609277"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200804804"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b02562"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06164-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201800011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b09109"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b01152"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201701974"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b02166"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201712878"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0403-361"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9024676"},{"key":"e_1_2_7_11_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.11.018"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b01370"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b11834"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508155"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b05512"},{"key":"e_1_2_7_13_4","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02293"},{"key":"e_1_2_7_13_5","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR04748K"},{"key":"e_1_2_7_13_6","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00259"},{"key":"e_1_2_7_13_7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004152"},{"key":"e_1_2_7_13_8","author":"Ran H. 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