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Hence, dual\u2010valent platinum nanoparticles (dvPtNPs) with a zero\u2010valent platinum core (Pt<jats:sup>0<\/jats:sup>) and bi\u2010valent platinum shell (Pt<jats:sup>2+<\/jats:sup> ions), combining photothermal and photodynamic therapy, together with \u201cchemotherapy,\u201d emerge as spatiotemporally light\u2010activatable platinum nano\u2010antibiotics. Under near\u2010infrared (NIR) exposure, the multiple antibacterial modes of dvPtNPs are triggered. The Pt<jats:sup>0<\/jats:sup> core reveals significant hyperthermia via effective photothermal conversion while an immediate release of chemotherapeutic Pt<jats:sup>2+<\/jats:sup> ions occurs through hyperthermia\u2010initiated destabilization of metallic interactions, together with reactive oxygen species (ROS) level increase, thereby resulting in synergistic antibacterial effects. The precise cooperative effects between photothermal, photodynamic, and Pt<jats:sup>2+<\/jats:sup> antibacterial effects are achieved on both Gram\u2010negative <jats:italic>Escherichia coli<\/jats:italic> and Gram\u2010positive methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>, where bacterial viability and colony\u2010forming units are significantly reduced. Moreover, similar results are observed in mice subcutaneous abscess models. Significantly, after NIR treatment, dvPtNP exhibits a more robust bacteria\u2010killing efficiency than other PtNP groups, owing to its integration of dramatic damage to the bacterial membrane and DNA, and alteration to ATP and ROS metabolism. 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