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With this goal in mind, a multivalent interactions\u2010based mucoadhesive nanogel for vaginal delivery is proposed. Briefly, the nanogel is constructed with mucoadhesive poly(acrylic acid) as the backbone and multiple inclusions between \u03b2\u2010cyclodextrin and paclitaxel as the crosslinking points. The in vitro experiments demonstrate that nanogel exerts high cytotoxicity to cancer cells, reverses multidrug resistance effectively, and successfully promotes the permeation of drugs. More to the point, as proved in the in vivo experiments, the retention time in the vagina is prolonged and the tumor growth is effectively suppressed by the nanogel without any side effects in the orthotopic cervical cancer model. As mentioned above, this novel mucoadhesive nanogel is believed to be a useful tool toward designing drug delivery systems for cervical cancer treatment.<\/jats:p>","DOI":"10.1002\/smll.201903208","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T09:52:01Z","timestamp":1571219521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A Paclitaxel\u2010Based Mucoadhesive Nanogel with Multivalent Interactions for Cervical Cancer Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Qiuhui","family":"Qian","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University  800 Dongchuan Road Shanghai 200240 P. R. 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