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However, the low theranostic performance of the current smart theranostics agents after the triggering step has limited their further application. In this work, the theranostic performance of endogenous H<jats:sub>2<\/jats:sub>S\u2010triggered Au@Cu<jats:sub>2<\/jats:sub>O for the diagnosis and treatment of colon cancer, which is generated from the localized surface plasmon resonance coupling effect between a noble metal (Au) and a semiconductor (Cu<jats:sub>2<\/jats:sub>O), is investigated. Compared with Cu<jats:sub>2<\/jats:sub>O, the prepared H<jats:sub>2<\/jats:sub>S\u2010triggered Au@Cu<jats:sub>2<\/jats:sub>O shows a significantly stronger absorption at the near\u2010infrared region, such as a \u22482.1 times change at 808 nm, giving a photothermal conversion efficiency increase of \u22481.2 times. More importantly, Au@Cu<jats:sub>2<\/jats:sub>O still exhibits good photoacoustic imaging contrast and photothermal properties for treatment of colon cancer in vivo even at very low injection doses. This work not only investigates an endogenous H<jats:sub>2<\/jats:sub>S\u2010triggered Au@Cu<jats:sub>2<\/jats:sub>O theranostic agent with enhanced theranostic performance for colon cancer but also provides a novel strategy for designing high\u2010performance theranostic agents.<\/jats:p>","DOI":"10.1002\/smll.201903473","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T13:34:01Z","timestamp":1568295241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Surface Plasmon Resonance\u2013Enhanced Photoacoustic Imaging and Photothermal Therapy of Endogenous H<sub>2<\/sub>S\u2010Triggered Au@Cu<sub>2<\/sub>O"],"prefix":"10.1002","volume":"15","author":[{"given":"Cheng","family":"Tao","sequence":"first","affiliation":[{"name":"The Key Laboratory of Resource Chemistry of the Ministry of Education the Shanghai Key Laboratory of Rare Earth Functional Materials and the Shanghai 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