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Herein, aiming at efficient photodynamic therapy (PDT) of bacterial infections and biofilm eradication of endophthalmitis, a pH\u2010responsive zeolitic imidazolate framework\u20108\u2010polyacrylic acid (ZIF\u20108\u2010PAA) material is constructed for bacterial infection\u2013targeted delivery of ammonium methylbenzene blue (MB), a broad\u2010spectrum photosensitizer antibacterial agent. Polyacrylic acid (PAA) is incorporated into the system to achieve higher pH responsiveness and better drug loading capacity. MB\u2010loaded ZIF\u20108\u2010PAA nanoparticles are modified with AgNO<jats:sub>3<\/jats:sub>\/dopamine for in situ reduction of AgNO<jats:sub>3<\/jats:sub> to silver nanoparticles (AgNPs), followed by a secondary modification with vancomycin\/NH<jats:sub>2<\/jats:sub>\u2010polyethylene glycol (Van\/NH<jats:sub>2<\/jats:sub>\u2010PEG), leading to the formation of a composite nanomaterial, ZIF\u20108\u2010PAA\u2010MB@AgNPs@Van\u2010PEG. Dynamic light scattering, transmission electron microscopy, and UV\u2013vis spectral analysis are used to explore the nanoparticles synthesis, drug loading and release, and related material properties. In terms of biological performance, in vitro antibacterial studies against three kinds of bacteria, i.e., <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic>, suggest an obvious superiority of PDT\/AgNPs to any single strategy. Both in vitro retinal pigment epithelium cellular biocompatibility experiments and in vivo mice endophthalmitis models verify the biocompatibility and antibacterial function of the composite nanomaterials.<\/jats:p>","DOI":"10.1002\/smll.201903880","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T07:57:14Z","timestamp":1570435034000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Synergistic Chemotherapy and Photodynamic Therapy of Endophthalmitis Mediated by Zeolitic Imidazolate Framework\u2010Based Drug Delivery Systems"],"prefix":"10.1002","volume":"15","author":[{"given":"Hao","family":"Chen","sequence":"first","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"},{"name":"Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Sciences  Wenzhou 32500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Inorganic Synthesis and Preparative Chemistry International Joint Research Laboratory of Nano\u2010Micro Architecture Chemistry (NMAC) College of Chemistry Jilin University  2699 Qianjin Street Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"},{"name":"Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Sciences  Wenzhou 32500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishun","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenya","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"},{"name":"Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Sciences  Wenzhou 32500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"},{"name":"MOE Key Laboratory of Macromolecule Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou 310027 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-8161","authenticated-orcid":false,"given":"Ying\u2010Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Inorganic Synthesis and Preparative Chemistry International Joint Research Laboratory of Nano\u2010Micro Architecture Chemistry (NMAC) College of Chemistry Jilin University  2699 Qianjin Street Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Ophthalmology &amp; Optometry Eye Hospital Wenzhou Medical University  Wenzhou 325027 China"},{"name":"Wenzhou Institute of Biomaterials and Engineering Chinese Academy of Sciences  Wenzhou 32500 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.09.013"},{"key":"e_1_2_7_2_1","first-page":"17","volume":"358","author":"Wang Y.","year":"2019","journal-title":"Chem. 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