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ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 \u00d7 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.<\/jats:p>","DOI":"10.1002\/smll.201905910","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T09:08:45Z","timestamp":1582708125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":181,"title":["Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid"],"prefix":"10.1002","volume":"16","author":[{"given":"Jixiang","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Bioengineering Center for Minimally Invasive Therapeutics University of California, Los Angeles  Los Angeles CA 90095 USA"},{"name":"Department of Biomedical Engineering School of Basic Medical Sciences Guangzhou Medical University  Guangzhou 511436 China"},{"name":"Affiliated Stomatology Hospital 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