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Herein, the construction of a multifunctional biomaterial system is reported by the integration of 2D Nb\n                    <jats:sub>2<\/jats:sub>\n                    C MXene wrapped with S\u2010nitrosothiol (R\uf8ffSNO)\u2010grafted mesoporous silica with 3D\u2010printing bioactive glass (BG) scaffolds (MBS). The near infrared (NIR)\u2010triggered photonic hyperthermia of MXene in the NIR\u2010II biowindow and precisely controlled nitric oxide (NO) release are coordinated for multitarget ablation of bone tumors to enhance localized osteosarcoma treatment. The in situ formed phosphorus and calcium components degraded from BG scaffold promote bone\u2010regeneration bioactivity, augmented by sufficient blood supply triggered by on\u2010demand NO release. The tunable NO generation plays a crucial role in sequential adjuvant tumor ablation, combinatory promotion of coupled vascularization, and bone regeneration. This study demonstrates a combinatory osteosarcoma ablation and a full osseous regeneration as enabled by the implantation of MBS. The design of multifunctional scaffolds with the specific features of controllable NO release, highly efficient photothermal conversion, and stimulatory bone regeneration provides an intriguing biomaterial platform for the diversified treatment of bone tumors.\n                  <\/jats:p>","DOI":"10.1002\/smll.201906814","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T09:16:29Z","timestamp":1582881389000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Engineering 2D Mesoporous Silica@MXene\u2010Integrated 3D\u2010Printing Scaffolds for Combinatory Osteosarcoma Therapy and NO\u2010Augmented Bone Regeneration"],"prefix":"10.1002","volume":"16","author":[{"given":"Qianhao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai 200233 P. R. 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