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Nowadays, diagnosis of a heart attack at early times is based on biochemical blood analysis (detection of cardiac enzymes) or by ultrasound\u2010assisted imaging. Alternative approaches are investigated to overcome the limitations of these classical techniques (time\u2010consuming procedures or low spatial resolution). As occurs in many other fields of biomedicine, cardiological preclinical imaging can also benefit from the fast development of nanotechnology. Indeed, bio\u2010functionalized near\u2010infrared\u2010emitting nanoparticles are herein used for in vivo imaging of the heart after an acute myocardial infarct. Taking advantage of the superior acquisition speed of near\u2010infrared fluorescence imaging, and of the efficient selective targeting of the near\u2010infrared\u2010emitting nanoparticles, in vivo images of the infarcted heart are obtained only a few minutes after the acute infarction event. This work opens an avenue toward cost\u2010effective, fast, and accurate in vivo imaging of the ischemic myocardium after an acute infarct.<\/jats:p>","DOI":"10.1002\/smll.201907171","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T04:12:22Z","timestamp":1592367142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Instantaneous In Vivo Imaging of Acute Myocardial Infarct by NIR\u2010II Luminescent Nanodots"],"prefix":"10.1002","volume":"16","author":[{"given":"Sergio","family":"Mateos","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda \u2013 Facultad de Medicina Fluorescence Imaging Group Avda. Arzobispo Morcillo 2 Universidad Aut\u00f3noma de Madrid  Madrid 28029 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-2448","authenticated-orcid":false,"given":"Jos\u00e9","family":"Lifante","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda \u2013 Facultad de Medicina Fluorescence Imaging Group Avda. Arzobispo Morcillo 2 Universidad Aut\u00f3noma de Madrid  Madrid 28029 Spain"},{"name":"Nanobiology Group Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria IRYCIS  Ctra. 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