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The majority of WGM sensors are passive resonators that require complex systems, thereby limiting their practicality. Active resonators enable the remote excitation and collection of WGM\u2010modulated fluorescence spectra, without requiring complex systems, and can be used as alternatives to passive microresonators. This paper demonstrates an active microresonator, which is a microdisk laser in a hyperboloid\u2010drum (HD) shape. The HD microdisk lasers are a combination of a rhodamine B\u2010doped photoresist and a silica microdisk. These HD microdisk lasers can be utilized for the detection of label\u2010free biomolecules. The biomolecule concentration can be as low as 1 ag mL<jats:sup>\u22121<\/jats:sup>, whereas the theoretical detection limit of the biosensor for human IgG in phosphate buffer saline is 9 ag mL<jats:sup>\u22121<\/jats:sup> (0.06 a<jats:sub>M<\/jats:sub>). Additionally, the biosensors are able to detect biomolecules in an artificial serum, with a theoretical detection limit of 9 ag mL<jats:sup>\u22121<\/jats:sup> (0.06 a<jats:sub>M<\/jats:sub>). These results are approximately four orders of magnitude more sensitive than those for the typical active WGM biosensors. The proposed HD microdisk laser biosensors show enormous detection potential for biomarkers in protein secretions or body fluids.<\/jats:p>","DOI":"10.1002\/smll.202000239","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T14:16:40Z","timestamp":1591625800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Hyperboloid\u2010Drum Microdisk Laser Biosensors for Ultrasensitive Detection of Human IgG"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-2829","authenticated-orcid":false,"given":"Zhihe","family":"Guo","sequence":"first","affiliation":[{"name":"Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education) Department of Optical Science and Engineering Shanghai Engineering Research Center of Ultra Precision Optical Manufacturing Fudan University  Shanghai 200433 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