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Herein, a light\u2010sensitive multiligand architecture is developed consisting of chitosan conjugated to a photosensitizer and 6'\u2010sialyllactose (SL) to develop an antiviral agent against influenza with a different mechanism of action (SL\u2010chitosan\u2010Chlorin e6, SCC). Saturation transfer difference\u2010nuclear magnetic resonance determined that the ability of SCC to bind to viral hemagglutinin is stronger than that of the monomeric substance. Virus recognition is confirmed by immunofluorescence and transmission electron microscope imaging. SCC induces viral inactivation by causing permanent membrane damage through its photoactivity. Viral membrane is oxidized by the photoactivity of SCC, thus, the virus membrane collapses. Furthermore, using the plaque reduction assay to evaluate the inhibitory effect of SCC on influenza A and B, it is found that its antiviral effects are 23% and 50% higher than the conventional antiviral drug. Additionally, SCC prevents infection by influenza in 100% of mice subjected to laser irradiation. These results indicate that this photodynamic multiligand structure can overcome the limitations of existing antiviral agents and suggest a pertinent methodology of prophylaxis and treatment by preemptively attacking the virus before it enters the host cell.<\/jats:p>","DOI":"10.1002\/smll.202000556","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T10:47:55Z","timestamp":1587725275000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Multiligand Architectural Photosensitizer That Targets Hemagglutinin on Envelope of Influenza Virus for Photodynamic Inactivation"],"prefix":"10.1002","volume":"16","author":[{"given":"Hayoon","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Biotechnology The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"},{"name":"Department of Biomedical\u2010Chemical Engineering The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangsu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"},{"name":"Department of Biomedical\u2010Chemical Engineering The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-0289","authenticated-orcid":false,"given":"Kun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Biotechnology The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"},{"name":"Department of Biomedical\u2010Chemical Engineering The Catholic University of Korea  43 Jibong\u2010ro, Wonmi\u2010gu Bucheon\u2010si Gyeonggi\u2010do 14662 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2175"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.08.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60074-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050740"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g2545"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001053"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.118"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2053"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2010.12.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100115"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100313"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054512"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.03.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0900648"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.129809"},{"key":"e_1_2_8_16_1","first-page":"153","volume":"82","author":"Samji T.","year":"2009","journal-title":"Yale J. 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