{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:58:18Z","timestamp":1791341898821,"version":"4.3.1"},"reference-count":65,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671394"],"award-info":[{"award-number":["81671394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873824"],"award-info":[{"award-number":["81873824"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701438"],"award-info":[{"award-number":["81701438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fine particulate matter (PM2.5) pollution arouses public health concerns over the world. Increasing epidemiologic evidence suggests that exposure to ambient airborne PM2.5 increases the risk of female infertility. However, relatively few studies have systematically explored the harmful effect of chronic PM2.5 exposure on ovarian function and the underlying mechanisms. In this study, female C57BL\/6J mice are exposed to filtered air or urban airborne PM2.5 for 4 months through a whole\u2010body exposure system. It is found that PM2.5 exposure significantly caused the alteration of estrus cycles, reproductivity, hormone levels, and ovarian reserve. The granulosa cell apoptosis via the mitochondria dependent pathway contributes to the follicle atresia. With RNA\u2010sequencing technique, the differentially expressed genes induced by PM2.5 exposure are mainly enriched in ovarian steroidogenesis, reactive oxygen species and oxidative phosphorylation pathways. Furthermore, it is found that increased PM2.5 profoundly exacerbated ovarian oxidative stress and inflammation in mice through the NF\u2010\u03baB\/IL\u20106 signaling pathway. Notably, dietary polydatin (PD) supplement has protective effect in mice against PM2.5\u2010induced ovarian dysfunction.These striking findings demonstrate that PM2.5 and\/or air pollution is a critical factor for ovarian dysfunction through mitochondria\u2010dependent and NF\u2010\u03baB\/IL\u20106\u2010mediated pathway, and PD may serve as a pharmaceutic candidate for air pollution\u2010associated ovarian dysfunction.<\/jats:p>","DOI":"10.1002\/smll.202000845","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T06:55:28Z","timestamp":1595228128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Ovarian Dysfunction Induced by Chronic Whole\u2010Body PM2.5 Exposure"],"prefix":"10.1002","volume":"16","author":[{"given":"Su","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Environment and Health College of Life Sciences University of Chinese Academy of Sciences  No. 19A Yuquan Road Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Wu","sequence":"additional","affiliation":[{"name":"Laboratory of Environment and Health College of Life Sciences University of Chinese Academy of Sciences  No. 19A Yuquan Road Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiyue","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Environment and Health College of Life Sciences University of Chinese Academy of Sciences  No. 19A Yuquan Road Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Ding","sequence":"additional","affiliation":[{"name":"Laboratory of Environment and Health College of Life Sciences University of Chinese Academy of Sciences  No. 19A Yuquan Road Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-952X","authenticated-orcid":false,"given":"Shixuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology  1095 Jiefang Ave Wuhan 430030 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32345-0"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1803222115"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.05.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.07.1110"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-017-0291-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev330"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0430-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.03.055"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2018.07.008"},{"key":"e_1_2_8_11_1","first-page":"52","volume":"37","author":"Veleminsky M.","year":"2016","journal-title":"Neuroendocrinol. Lett."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.01.009"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.06.075"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.10.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.08.081"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252499499"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2011.563508"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/19396368.2010.500440"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2009.03.006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.958992"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.01.103"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.8b00625"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105338"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.207472"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7180943"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.748033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.05.007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1737185"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-019-0191-3"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.255972"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5936"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.07.002"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.06.014"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.792849"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.08.013"},{"key":"e_1_2_8_37_1","first-page":"7196535","volume":"2019","author":"Zheng L.","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.2011-012"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.349"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.30369"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01474"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2016.07.094"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40030"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818134116"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.104118"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1714"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2270"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.05.008"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-014-0980-5"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14070816"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey005"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001029"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.12.023"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124746"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0006"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-31973-5_7"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.21451\/1984-3143-AR2019-0051"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-31973-5_8"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0365-7"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0030"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01057A"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02527"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-10-4"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.09.011"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102016"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fsmll.202000845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202000845","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202000845","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202000845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T13:56:44Z","timestamp":1693922204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202000845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,19]]},"references-count":65,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/smll.202000845"],"URL":"https:\/\/doi.org\/10.1002\/smll.202000845","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,19]]},"assertion":[{"value":"2020-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000845"}}