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However, many catalysts, such as graphene, are barely dispersible in aqueous media and many chemical reactions cannot be performed in the presence of water due to thermodynamic limitations. Therefore, there is an urgent need to develop novel strategies to carry out these processes in more sustainable conditions. To pursue this goal, in this work, a waterborne supramolecular nanoreactor is developed. The system comprises a polymeric micelle obtained from the self\u2010assembly of pyrrole\u2010based amphiphilic block copolymers. The active catalytic component is represented by few graphene layers, functionalized with pyrrole to enhance their interaction with the micelle core and hence their nanoencapsulation. Using this nanoreactor, it is possible to synthesize imines starting from primary amines and aldehydes or ketones with high yield and in short time (<jats:italic>Y<\/jats:italic> = 90% after 5 min) at room temperature. Moreover, an efficient strategy to recycle the reactor is proposed, thus increasing the potential of this technology.<\/jats:p>","DOI":"10.1002\/smll.202001207","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T15:02:48Z","timestamp":1600959768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Graphene\u2010Based Supramolecular Nanoreactor for the Fast Synthesis of Imines in Water"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-491X","authenticated-orcid":false,"given":"Umberto","family":"Capasso Palmiero","sequence":"first","affiliation":[{"name":"Department of Chemistry and Applied Bioscience ETH Zurich  Vladimir\u2010Prelog\u2010Weg 1\u20105 Zurich 8093 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