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Devising pharmacological nanomaterials for tumor\u2010specific H<jats:sub>2<\/jats:sub>S activation will be significant for precise colon cancer treatment. Herein, a biocompatible fusiform iron oxide\u2010hydroxide nanospindles (FeOOH NSs) nanosystem for magnetic resonance imaging (MRI), ferroptosis, and H<jats:sub>2<\/jats:sub>S based cascade reaction\u2010enhanced combinational colon cancer treatment is developed. The FeOOH NSs can effectively scavenge endogenous H<jats:sub>2<\/jats:sub>S via the reduction reaction to prohibit the growth of CT26 colon cancer. The cascade produced FeS driven by overexpressed H<jats:sub>2<\/jats:sub>S exhibits near\u2010infrared\u2010triggered photothermal therapy capability and Fe<jats:sup>2+<\/jats:sup>\u2010mediated ferroptosis functionality. Meanwhile, the as\u2010prepared FeOOH NSs can light up tumor tissues as a potent MRI contrast agent. Additionally, FeOOH NSs present desirable biosafety in a murine model for up to three months and avoid any long\u2010term toxicity. Furthermore, it is found that these H<jats:sub>2<\/jats:sub>S\u2010responsible nanotheranostics do not cause any cure effects on other cancer types, such as 4T1 breast cancer. Overall, the findings illustrate that the biocompatible FeOOH NSs can be successfully employed as a theranostic for specifically treating colon cancer, which may promote the clinical translation and development of H<jats:sub>2<\/jats:sub>S\u2010responsive nanoplatforms.<\/jats:p>","DOI":"10.1002\/smll.202001356","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T07:16:28Z","timestamp":1597302988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["H<sub>2<\/sub>S\u2010Scavenged and Activated Iron Oxide\u2010Hydroxide Nanospindles for MRI\u2010Guided Photothermal Therapy and Ferroptosis in Colon Cancer"],"prefix":"10.1002","volume":"16","author":[{"given":"Yangyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 322000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular Imaging Program at Stanford Department of Radiology Stanford University  Stanford CA 94305\u20105427 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 322000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 322000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences School of Life Sciences East China Normal University  Shanghai 200241 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Zhejiang University  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine Zhejiang University  Hangzhou 310009 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanle","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Radiology Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang 310016 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 322000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-9570","authenticated-orcid":false,"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Surgery The Fourth Affiliated Hospital Zhejiang University School of Medicine  Yiwu 322000 China"},{"name":"Institute of Translational Medicine Zhejiang University  Hangzhou 310009 China"},{"name":"State Key Laboratory of Modern Optical Instrumentations Zhejiang University  Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.10.007"},{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010197"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0209-6"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.59"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1226"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3599"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.52.1.8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4433"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306241110"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20090368"},{"key":"e_1_2_7_7_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113775"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201903473"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901724"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2006.12.019"},{"key":"e_1_2_7_11_2","first-page":"2852","volume":"1","author":"Chen M. 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