{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T14:12:04Z","timestamp":1774966324994,"version":"3.50.1"},"reference-count":171,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the latest advances in cardiovascular biology and medicine, myocardial infarction (MI) remains one of the major causes of deaths worldwide. While reperfusion of the myocardium is critical to limit the ischemic damage typical of a MI event, it causes detrimental morphological and functional changes known as \u201creperfusion injury.\u201d This complex scenario is poorly represented in currently available models of ischemia\/reperfusion injury, leading to a poor translation of findings from the bench to the bedside. However, more recent bioengineered in vitro models of the human heart represent more clinically relevant tools to prevent and treat MI in patients. These include 3D cultures of cardiac cells, the use of patient\u2010derived stem cells, and 3D bioprinting technology. This review aims at highlighting the major features typical of a heart attack while comparing current in vitro, ex vivo, and in vivo models. This information has the potential to further guide in developing novel advanced in vitro cardiac models of ischemia\/reperfusion injury. It may pave the way for the generation of advanced pathophysiological cardiac models with the potential to develop personalized therapies.<\/jats:p>","DOI":"10.1002\/smll.202003765","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T14:09:29Z","timestamp":1611065369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction"],"prefix":"10.1002","volume":"17","author":[{"given":"Poonam","family":"Sharma","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health University of Newcastle  Newcastle NSW 2308 Australia"},{"name":"School of Medicine and Public Health University of Sydney  Sydney NSW 2000 Australia"},{"name":"Kolling Institute of Medical Research Royal North Shore Hospital  Sydney NSW 2065 Australia"},{"name":"School of Biomedical Engineering\/FEIT University of Technology Sydney  Building 11, Level 10, Room 115, 81 Broadway Ultimo NSW 2007 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Imaging and Theranostics Laboratory Baker Heart and Diabetes Institute  Melbourne VIC 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara Liu Chung","family":"Ming","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering\/FEIT University of Technology Sydney  Building 11, Level 10, Room 115, 81 Broadway Ultimo NSW 2007 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Vettori","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering\/FEIT University of Technology Sydney  Building 11, Level 10, Room 115, 81 Broadway Ultimo NSW 2007 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Figtree","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Sydney  Sydney NSW 2000 Australia"},{"name":"Kolling Institute of Medical Research Royal North Shore Hospital  Sydney NSW 2065 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Boyle","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Newcastle  Newcastle NSW 2308 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-4275","authenticated-orcid":false,"given":"Carmine","family":"Gentile","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Sydney  Sydney NSW 2000 Australia"},{"name":"Kolling Institute of Medical Research Royal North Shore Hospital  Sydney NSW 2065 Australia"},{"name":"School of Biomedical Engineering\/FEIT University of Technology Sydney  Building 11, Level 10, Room 115, 81 Broadway Ultimo NSW 2007 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_7_1_1","author":"Joshua Chadwick J.","year":"2019","journal-title":"IntechOpen"},{"key":"e_1_2_7_2_1","unstructured":"Global Facts and Figures World Heart Federation 2017."},{"key":"e_1_2_7_3_1","volume-title":"StatPearls","author":"Ojha N.","year":"2019"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.171600"},{"key":"e_1_2_7_5_1","unstructured":"Cardiovascular Diseases World Health Organization 2017."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.072"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1124"},{"key":"e_1_2_7_8_1","first-page":"68","volume":"76","author":"Das D. K.","year":"1987","journal-title":"Ann. Chir. Gynaecol."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00024.2007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.55.6.816"},{"key":"e_1_2_7_11_1","first-page":"99","volume":"76","author":"Lemasters J. J.","year":"1996","journal-title":"EXS"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312356"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew267"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca.12.58"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.883533"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs116"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.313"},{"key":"e_1_2_7_18_1","first-page":"864946","author":"Zhou T.","year":"2015","journal-title":"BioMed Res. Int."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62874"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v10.i9.74"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010715-103335"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v6.i7.638"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2016-0132"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-0971-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.036"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874120701007010001"},{"key":"e_1_2_7_28_1","first-page":"765","volume":"8","author":"Yang Q.","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00134.2018"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz070"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(09)70023-5"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.10.007"},{"key":"e_1_2_7_33_1","first-page":"e51671","volume":"88","author":"Schechter M. A.","year":"2014","journal-title":"JoVE"},{"key":"e_1_2_7_34_1","first-page":"e52908","volume":"101","author":"Herr D. J.","year":"2015","journal-title":"JoVE"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00333.2012"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.018"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.06.080"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0653"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-69194-7_13"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b15019"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00335.2017"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00069-8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd3040030"},{"key":"e_1_2_7_44_1","first-page":"70","volume":"6","author":"Camacho P.","year":"2016","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay2140"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.11.026"},{"key":"e_1_2_7_47_1","first-page":"e52197","volume":"99","author":"Curaj A.","year":"2015","journal-title":"JoVE"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00339.2017"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40883-018-0056-0"},{"key":"e_1_2_7_50_1","first-page":"e51329","volume":"86","author":"Xu Z.","year":"2014","journal-title":"JoVE"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0040-4"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/27.12.2274"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.08.004"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01564"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15120"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S195412"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12801"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718786882"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.41"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000480317"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.07.004"},{"key":"e_1_2_7_62_1","first-page":"1321","volume":"43","author":"Ren Z.","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"e_1_2_7_63_1","first-page":"2331","volume":"44","author":"Yang P.","year":"2019","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10701"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173657"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1174-4"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2018.0212"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X10666151001114848"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa093"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06385-8"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477436"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00087"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.85.12.e70"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0405-367"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248412475158"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0673-4"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-254854"},{"key":"e_1_2_7_78_1","first-page":"7156","volume":"17","author":"Chen S.","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-018-0674-1"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.2039"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4298945"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.04.011"},{"key":"e_1_2_7_83_1","first-page":"2738","volume":"7","author":"Hosoyama T.","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25553"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-019-0155-6"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2014.573"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2017"},{"key":"e_1_2_7_88_1","first-page":"190","volume":"6","author":"Sharma P.","year":"2017","journal-title":"J. Stem Cell Res. Ther."},{"key":"e_1_2_7_89_1","first-page":"387","volume-title":"Encyclopedia of Tissue Engineering and Regenerative Medicine","author":"Campbell M.","year":"2019"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00534.2001"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5000746"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2019.09.001"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-0539-4"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00036.2016"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1174-4"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.11.036"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1557\/mrs2003.85"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407817101"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.888"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.8.9240969"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0290(20000405)68:1<106::AID-BIT13>3.0.CO;2-3"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0202.103644"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.04.011"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2524"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.300522"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.06.022"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0302.105722"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001317"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.055"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-013-0528-2"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198026"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.089"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.04.006"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5341702"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201650"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.084343"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.06.036"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.09.025"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-019-00325-2"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.36.11"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2034fje"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01316"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5250"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/7651_2018_187"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632704322791853"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908381106"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.07.021"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.2986"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c00076"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5LC01356A"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2019.0002"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.mcb.2018.05.005"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472630317705610"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.09.003"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107453"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab5158"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712590903563352"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.02.007"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/8\/1\/013001"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.07.014"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31848-x"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900344"},{"key":"e_1_2_7_143_1","first-page":"5","volume":"8","author":"Valk D. C.","year":"2018","journal-title":"Nanomaterials"},{"key":"e_1_2_7_144_1","first-page":"e55438","volume":"125","author":"Ong C. S.","year":"2017","journal-title":"JoVE"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000257776.05673.ff"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-017-9736-2"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering4030071"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S189587"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071910-124701"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma11112199"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5128371"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.07.020"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5082\/6\/2\/024109"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.09.024"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.211458"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310738"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.242354"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187348"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.039711"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.016"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0130"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.033"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009275"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1391"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052176"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0625-4"},{"key":"e_1_2_7_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.05.042"},{"key":"e_1_2_7_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.06.034"},{"key":"e_1_2_7_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.05.002"},{"key":"e_1_2_7_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05604-8"},{"key":"e_1_2_7_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2019.04.004"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202003765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202003765","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202003765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T17:45:54Z","timestamp":1692726354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202003765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":171,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/smll.202003765"],"URL":"https:\/\/doi.org\/10.1002\/smll.202003765","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"2020-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2003765"}}