{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:24:39Z","timestamp":1781058279397,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91850110"],"award-info":[{"award-number":["91850110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11775136"],"award-info":[{"award-number":["11775136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Due to the widespread antibiotic\u2010resistant microbes and the slow development in antibiotics, innovative new antibacterial agents are eagerly desired to control infection in the resistance era. Here, it is demonstrated that the antibacterial ability against drug\u2010resistant bacteria can be endowed to transition metal dichalcogenides (XS<jats:sub>2<\/jats:sub>, X = Mo\/W) quantum dots by sulfur vacancies, and their application in bacterial keratitis. The sulfur vacancies are generated by the ion irradiation with the controlled influences, which ensures the one\u2010way electron transport from the external environment to XS<jats:sub>2<\/jats:sub> leading to a strong reactive oxygen speciesindependent oxidative stress. With the concentration of 140 \u00b5g mL<jats:sup>\u22121<\/jats:sup> of XS<jats:sub>2\u20130.1<\/jats:sub> quantum dots, the sterilization efficiency of Gram\u2010positive <jats:italic>Staphylococcus aureus<\/jats:italic> and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> more than 99.9% within 20 min at room temperature in the dark is realized. For biomedical application against bacterial keratitis, it is observed that the occurrence of severe clinical manifestation like ocular perforation can be prevented. This work demonstrates the vacancy as a novel, simple, and effective strategy to tune XS<jats:sub>2<\/jats:sub> as the antibacterial agent with a fast response and no reliance on light that has significant potential therapeutic effects on clinical drug resistant bacterial keratitis.<\/jats:p>","DOI":"10.1002\/smll.202004677","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T07:23:03Z","timestamp":1600327383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Vacancy\u2010Induced Antibacterial Activity of XS<sub>2\u2013<\/sub><i><sub>y<\/sub><\/i> Quantum Dots against Drug\u2010Resistant Bacteria for Treatment of Bacterial Keratitis"],"prefix":"10.1002","volume":"16","author":[{"given":"Huiyuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong 250012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Laboratory Diagnosis Center Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong 250013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong 250033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong 250013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Pei","sequence":"additional","affiliation":[{"name":"Medical Laboratory Diagnosis Center Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong 250013 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The Second Hospital Cheeloo College of Medicine Shandong University  Jinan Shandong 250033 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7912-1742","authenticated-orcid":false,"given":"Yang","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Physics State Key Laboratory of Crystal Materials Shandong University  Jinan Shandong 250100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Physics State Key Laboratory of Crystal Materials Shandong University  Jinan Shandong 250100 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41576-019-0174-7","volume":"20","author":"Koch L.","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1791-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22308"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2191"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1791-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.75"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrmicro.2018.33","volume":"16","author":"Lo S. W.","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.7.834"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2013.790978"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3201\/eid2305.161745","volume":"23","author":"Murray G. L.","year":"2017","journal-title":"Emerging Infect. Dis."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4542"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00318A"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2017.33"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201304497"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600633"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201403264"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b04606"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12967"},{"key":"e_1_2_6_19_1","first-page":"188","volume":"35","author":"Greaves J. L.","year":"1993","journal-title":"Br. J. Clin. Pharmacol."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.03.043"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201606760"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00024G"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR02025B"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06503"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201805710"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201402680"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR08384B"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201102015"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201500709"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.93"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017200108"},{"key":"e_1_2_6_32_1","first-page":"847","volume":"36","author":"Brock T. D.","year":"1961","journal-title":"Acad. Med."}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202004677","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202004677","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202004677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:52:18Z","timestamp":1693871538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202004677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":32,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1002\/smll.202004677"],"URL":"https:\/\/doi.org\/10.1002\/smll.202004677","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,16]]},"assertion":[{"value":"2020-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2004677"}}