{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:25Z","timestamp":1786978465589,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Nos.21874079"],"award-info":[{"award-number":["Nos.21874079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Bacterial infections have become a major danger to public health because of the appearance of the antibiotic resistance. The synergistic combination of multiple therapies should be more effective compared with the respective one alone, but has been rarely demonstrated in combating bacterial infections till now. Herein, oxygen\u2010vacancy molybdenum trioxide nanodots (MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    NDs) are proposed as an efficient and safe bacteriostatic. The MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    NDs alone possess triple\u2010therapy synergistic efficiency based on the single near\u2010infrared irradiation (808 nm) regulated combination of photodynamic, photothermal, and peroxidase\u2010like enzymatic activities. Therein, photodynamic and photothermal therapies can be both achieved under the excitation of a single wavelength light source (808 nm). Both the photodynamic and nanozyme activity can result in the generation of reactive oxygen species (ROS) to reach the broad\u2010spectrum sterilization. Interestingly, the photothermal effect can regulate the MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    NDs to their optimum enzymatic temperature (50 \u00b0C) to give sufficient ROS generation in low concentration of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    (100 \u00b5\n                    <jats:sc>m<\/jats:sc>\n                    ). The MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    NDs show excellent antibacterial efficiency against drug\u2010resistance extended spectrum \u03b2\u2010lactamases producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA). Animal experiments further indicate that the MoO\n                    <jats:sub>3\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    NDs can effectively treat wounds infected with MRSA in living systems.\n                  <\/jats:p>","DOI":"10.1002\/smll.202005739","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T10:32:52Z","timestamp":1607337172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Near\u2010Infrared Regulated Nanozymatic\/Photothermal\/Photodynamic Triple\u2010Therapy for Combating Multidrug\u2010Resistant Bacterial Infections via Oxygen\u2010Vacancy Molybdenum Trioxide Nanodots"],"prefix":"10.1002","volume":"17","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxia","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"},{"name":"Department of Urology Key Laboratory of Urinary System Diseases The Affiliated Hospital of Qingdao University  Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshan","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhishang","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishuai","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-9820","authenticated-orcid":false,"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Sciences Qingdao University  Qingdao 266071 China"},{"name":"Department of Urology Key Laboratory of Urinary System Diseases The Affiliated Hospital of Qingdao University  Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17042"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12790"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22507"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1145"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201407145"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.153"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.10.053"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn202451x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn101558x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.06.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn100866w"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn101390x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja410800y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn101097v"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2013.125"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200437"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050335"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2012.03.020"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049215"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.260"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn501640q"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201701146"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR01243D"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507140"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b18146"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.10.044"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201604300"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn506107c"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18032712"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2009.04.001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NR08930F"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201904397"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900157"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b11553"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2006.07.004"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201510597"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1369-7021(11)70165-1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm0206237"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB00475G"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2007.07.016"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2019.127512"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201603689"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b00088"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201801523"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b11316"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2019.11.010"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b11316"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5012014"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201809492"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807576"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2018.11.047"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja501866r"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.8b06985"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201705734"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnma.201800257"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijhydene.2018.12.015"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.364"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00500H"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2007.260"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/am5057129"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201801484"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-015-1690-6"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200903783"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2019.11.093"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2019.09.040"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b01327"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202005739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202005739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202005739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T06:36:09Z","timestamp":1693722969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202005739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,7]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/smll.202005739"],"URL":"https:\/\/doi.org\/10.1002\/smll.202005739","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,7]]},"assertion":[{"value":"2020-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2005739"}}