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While hormonal treatments have greatly improved fertility results for some women, these responses remain unsatisfactory due to damage and infection of the complex endometrial microenvironment. In this study, a multifunctional microenvironment\u2010protected exosome\u2010hydrogel is designed for facilitating endometrial regeneration and fertility restoration via in situ microinjection and endometrial regeneration. This exosome hydrogel is formulated via Ag\n                    <jats:sup>+<\/jats:sup>\n                    \u2010S dynamic coordination and fusion with adipose stem cell\u2010derived exosomes (ADSC\u2010exo), yielding an injectable preparation that is sufficient to mitigate infection risk while also possessing the antigenic contents and paracrine signaling activity of the ADSC source cells, enabling regeneration of the endometrial microenvironment. In vitro, this exosome\u2010hydrogel exerts an outstanding neovascularization\u2010promoting effect, increased human umbilical vein endothelial cell proliferation and tube formation for 1.87 and 2.2 folds. In vivo, microenvironment\u2010protected exosome\u2010hydrogel also reveals to promote neovascularization and tissue regeneration while suppressing local tissue fibrosis. Importantly, regenerated endometrial tissue is more receptive to give embryos and birth to a healthy newborn. This microenvironment\u2010protected exosome\u2010hydrogel system offers a convenient, safe, and noninvasive approach for repairing thin endometrium and fertility restoration.\n                  <\/jats:p>","DOI":"10.1002\/smll.202007235","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T20:59:27Z","timestamp":1613681967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Microenvironment\u2010Protected Exosome\u2010Hydrogel for Facilitating Endometrial Regeneration, Fertility Restoration, and Live Birth of Offspring"],"prefix":"10.1002","volume":"17","author":[{"given":"Jiaying","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  639 Zhizaoju Road Shanghai 200011 P. R. 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