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Sensing these biochemicals in the human body has the potential to significantly advance medical research and clinical applications. In this work, a nanosensor platform consisting of single\u2010walled carbon nanotubes (SWCNTs) with nanoparticle corona phases engineered to allow for the selective molecular recognition of ascorbic acid and riboflavin, is developed. The study provides a methodological framework for the implementation of colloidal SWCNT nanosensors in an intraperitoneal SKH1\u2010E murine model by addressing complications arising from tissue absorption and scattering, mechanical perturbations, as well as sensor diffusion and interactions with the biological environment. Nanosensors are encapsulated in a polyethylene glycol diacrylate hydrogel and a diffusion model is utilized to validate analyte transport and sensor responses to local concentrations at the boundary. Results are found to be reproducible and stable after exposure to 10% mouse serum even after three days of in vivo implantation. A geometrical encoding scheme is used to reference sensor pairs, correcting for in vivo optical and mechanical artifacts, resulting in an order of magnitude improvement of <jats:italic>p<\/jats:italic>\u2010value from 0.084 to 0.003 during analyte sensing.<\/jats:p>","DOI":"10.1002\/smll.202100540","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T16:19:06Z","timestamp":1624810746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Transcutaneous Measurement of Essential Vitamins Using Near\u2010Infrared Fluorescent Single\u2010Walled Carbon Nanotube Sensors"],"prefix":"10.1002","volume":"17","author":[{"given":"Naveed A.","family":"Bakh","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-2768","authenticated-orcid":false,"given":"Xun","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojia","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr B.","family":"Koman","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-808X","authenticated-orcid":false,"given":"Michael S.","family":"Strano","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Massachusetts Institute of Technology  77 Massachusetts Ave. Cambridge MA 02139 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072149"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/66\/2\/204"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2006.891486"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac199971122333"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.01.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2010.07.008"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0956-5663(94)80107-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00087a008"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002853"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000429"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3337"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2005.08.054"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(01)00836-4"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"e0196970","DOI":"10.1371\/journal.pone.0196970","volume":"13","author":"Bhat D. 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