{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:33:20Z","timestamp":1792607600618,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"32","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A2B3005842"],"award-info":[{"award-number":["2017R1A2B3005842"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C2085516"],"award-info":[{"award-number":["2019R1A2C2085516"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Severe cardiac damage following myocardial infarction (MI) causes excessive inflammation, which sustains tissue damage and often induces adverse cardiac remodeling toward cardiac function impairment and heart failure. Timely resolution of post\u2010MI inflammation may prevent cardiac remodeling and development of heart failure. Cell therapy approaches for MI are time\u2010consuming and costly, and have shown marginal efficacy in clinical trials. Here, nanoparticles targeting the immune system to attenuate excessive inflammation in infarcted myocardium are presented. Liposomal nanoparticles loaded with MI antigens and rapamycin (L\u2010Ag\/R) enable effective induction of tolerogenic dendritic cells presenting the antigens and subsequent induction of antigen\u2010specific regulatory T cells (Tregs). Impressively, intradermal injection of L\u2010Ag\/R into acute MI mice attenuates inflammation in the myocardium by inducing Tregs and an inflammatory\u2010to\u2010reparative macrophage polarization, inhibits adverse cardiac remodeling, and improves cardiac function. Nanoparticle\u2010mediated blocking of excessive inflammation in infarcted myocardium may be an effective intervention to prevent the development of post\u2010MI heart failure.<\/jats:p>","DOI":"10.1002\/smll.202101207","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T10:35:36Z","timestamp":1625308536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Nanoparticle\u2010Mediated Blocking of Excessive Inflammation for Prevention of Heart Failure Following Myocardial Infarction"],"prefix":"10.1002","volume":"17","author":[{"given":"Sung Pil","family":"Kwon","sequence":"first","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Hee","family":"Hwang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Hye","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Young","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010Ro","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikyung","family":"Kang","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program for Bioengineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seuk Young","family":"Song","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mungyo","family":"Jung","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Su","family":"Sohn","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu Chul","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunho","family":"Choo","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute for Intractable Disease Division of Cardiology Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea  Seoul 06591 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhyun","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Chemical and Biological Engineering Seoul National University  Seoul 08826 Republic of 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