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Fullerenol, known as \u201cfree radical sponge,\u201d is a great choice for skin radioprotection because of its broad\u2010spectrum free radical scavenging performance, good chemical stability, and biosafety. In this work, a facile scalable and eco\u2010friendly synthetic method of fullerenols by catalyst assistant mechanical chemistry strategy is provided. As no organic solvent or high concentration of acid and alkali is introduced to this synthetic system, large\u2010scale (&gt;20\u00a0g) production of fullerenols with high yield (&gt;95%) is obtained and no complicated purification is required. Then, the skin radioprotective performance of fullerenols is systematically explored for the first time. In vitro results indicate that fullerenols significantly block the reactive oxygen species\u2010induced damage and enhance the viability of irradiated human keratinocyte cells. In vivo experiments suggest that medical sodium hyaluronate hydrogels loaded with fullerenols are suitable for skin administration and powerfully mitigate radiodermatitis via effectively protecting epidermal stem cells. The work not only provides an efficient gram\u2010scale and eco\u2010friendly synthetic method of fullerenols, but also promotes the development of fullerenols as potential skin radioprotectors.<\/jats:p>","DOI":"10.1002\/smll.202102035","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:05:49Z","timestamp":1627862749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Eco\u2010Friendly and Scalable Synthesis of Fullerenols with High Free Radical Scavenging Ability for Skin Radioprotection"],"prefix":"10.1002","volume":"17","author":[{"given":"Maoru","family":"Zhao","sequence":"first","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences  Beijing 100049 China"},{"name":"Center of Materials Science and Optoelectronics Engineering College of Materials Science and Optoelectronic Technology University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Wang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences  Beijing 100049 China"},{"name":"Center of Materials Science and Optoelectronics Engineering College of Materials Science and Optoelectronic Technology University of Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Biological Engineering Chengdu University  Chengdu 610106 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ji","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory for Biomedical Effects of Nanomaterials and 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