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However, the clinical translation of gas therapy remains challenging due to the rapid diffusion and limited tissue penetration of therapeutic gases. Herein, a self\u2010propelled, asymmetrical Au@MnO<jats:sub>2<\/jats:sub> nanomotor for efficient delivery of therapeutic gas to deep\u2010seated cancer tissue for enhanced efficacy of gas therapy, is reported. The Au@MnO<jats:sub>2<\/jats:sub> nanoparticles (NPs) catalyze endogenous H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> into O<jats:sub>2<\/jats:sub> that propels NPs into deep solid tumors, where SO<jats:sub>2<\/jats:sub> prodrug is released from the hollow NPs owing to the degradation of MnO<jats:sub>2<\/jats:sub> shells. Fluorescein isothiocyanate (FITC) is conjugated onto the surface of Au via caspase\u20103 responsive peptide (DEVD) and the therapeutic process of gas therapy can be optically self\u2010reported by the fluorescence of FITC that is turned on in the presence of overexpressed caspase\u20103 as an apoptosis indicator. Au@MnO<jats:sub>2<\/jats:sub> nanomotors show self\u2010reported therapeutic efficacy and high biocompatibility both in vitro and in vivo, offering important new insights to the design and development of novel nanomotors for efficient payload delivery into deep tumor tissue and in situ monitoring of the therapeutic process.<\/jats:p>","DOI":"10.1002\/smll.202102286","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T08:31:54Z","timestamp":1626251514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Self\u2010Propelled Asymmetrical Nanomotor for Self\u2010Reported Gas Therapy"],"prefix":"10.1002","volume":"17","author":[{"given":"Ludan","family":"Yue","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau  Taipa Macau SAR 999078 P. R. 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