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Construction of a safe and efficient photothermal antibacterial platform is a promising strategy for treatment of bacterial infections. Considering that high temperature does harm to the normal tissues and cells, herein, a bacteria\u2010triggered multifunctional hydrogel is constructed for low\u2010temperature photothermal sterilization with high efficiency by integrating localized chemodynamic therapy (L\u2010CDT). The hydrogel is constructed by incorporating copper sulfide nanoparticles (CuS<jats:sub>NPs<\/jats:sub>) with photothermal profile into the network of hyaluronic acid (HA) and Fe<jats:sup>3+<\/jats:sup>\u2010EDTA complexes, named as CHFH (CuS<jats:sub>NPs<\/jats:sub>\u2010HA\u2010Fe<jats:sup>3+<\/jats:sup>\u2010EDTA hydrogel). Bacteria can be accumulated on the surface of CHFH, which secretes hyaluronidase to decompose the HA and release Fe<jats:sup>3+<\/jats:sup>. The Fe<jats:sup>3+<\/jats:sup> is reduced into Fe<jats:sup>2+<\/jats:sup> in microenvironment of bacteria to trigger Fenton reaction. The generated hydroxyl radicals result in sterilization based on L\u2010CDT within short range. By integrating with photothermal property of CuS<jats:sub>NPs<\/jats:sub>, low\u2010temperature photothermal therapy (LT\u2010PTT) for sterilization is realized, which improves the antibacterial efficiency while minimizes damage to normal tissues. The CHFH is further used to prepare Band aid which effectively promotes the <jats:italic>Staphylococcus aureus<\/jats:italic>\u2010infected wound healing process in vivo, confirming the great potential for clinical application.<\/jats:p>","DOI":"10.1002\/smll.202103303","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T19:56:26Z","timestamp":1634414186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Bacteria\u2010Triggered Multifunctional Hydrogel for Localized Chemodynamic and Low\u2010Temperature Photothermal Sterilization"],"prefix":"10.1002","volume":"17","author":[{"given":"Xiaodong","family":"Lin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Nutrition and Safety College of Food Science and Engineering Tianjin University of Science and Technology  Tianjin 300457 P. R. 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