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The current treatment strategy is called quadruple therapy and includes proton pump inhibitors, bismuth, and two broad\u2010band antibiotics. This fact may affect medication compliance, leading to a resistance rate of more than 25% to clarithromycin or metronidazole. To counter this, from the perspective of natural products, an intragastric\u2010targeting all\u2010in\u2010one theranostic platform is established: a drug carrier microcapsule composed of multiple synergistic antiulcer drugs, including bismuth, gallotannin, and antibiotics is obtained (BiG@MCs), and the therapeutic effects of BiG@MCs in rodent models are further evaluated. The results show that the BiG@MCs are spherical with homogeneous particle size (3\u00a0\u00b1 0.5\u00a0\u00b5m) and can be response\u2010released to the acidic environment of the stomach (pH 2.0\u20133.0), preventing the premature release of the BiG@MCs in physiological conditions. It is worth noting that the bismuth component can be easily identified by computed tomography and other detection instruments, which provide the possibility for drug tracing. In summary, these results indicate that BiG@MCs provide a versatile intragastric\u2010targeting drug delivery platform for GU therapeutics.<\/jats:p>","DOI":"10.1002\/smll.202104660","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T09:00:01Z","timestamp":1644310801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["All\u2010in\u2010One Theranostic Platform Based on Hollow Microcapsules for Intragastric\u2010Targeting Antiulcer Drug Delivery, CT Imaging, and Synergistically Healing Gastric Ulcer"],"prefix":"10.1002","volume":"18","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Xinjiang Endemic Phytomedicine Resources Ministry of Education Shihezi University College of Pharmacy  Shihezi 832003 P. R. 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