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The efficacy of the arisen immune checkpoint therapy is still uncertain due to local immunosuppression. In order to further overcome T cell suppression in the tumor immune microenvironment while promoting the immune response of antigen\u2010presenting cells, a biointerfacing antagonizing T\u2010cell inhibitory nanoparticles (BAT NPs) has been developed by cloaking platelet membrane on the PLGA microsphere surface to load T\u2010cell immunoglobulin domain and mucin domain\u20103 antibodies (anti\u2010TIM\u20103) as well as PD\u2010L1. Notably, in addition to activating the proliferation and migration of T cells, the contained anti\u2010TIM\u20103 can cooperate with PD\u2010L1 checkpoint blockade to exert therapeutic effects. Furthermore, the components of BAT NPs like anti\u2010TIM\u20103 and platelet can act together for collagen deposition in tumor starvation treatment. Thus, a novel targeting therapeutic strategy that can effectively reverse the immune\u2010inhibiting microenvironment is effectively applied to PD\u2010L1 checkpoint combination therapy. Such therapeutic effect can subsequently activate the effector T lymphocytes and antigen presentation of dendritic cells as well as the polarization of M1\u2010type macrophages. Last, the study presented the synergistic effect of immune therapeutic adjuvants and BAT NPs components in achieving tumor inhibition and prolonging tumor\u2010burden survival.<\/jats:p>","DOI":"10.1002\/smll.202105237","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T05:06:21Z","timestamp":1637211981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biointerfacing Antagonizing T\u2010Cell Inhibitory Nanoparticles Potentiate Hepatocellular Carcinoma Checkpoint Blockade Therapy"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-3600","authenticated-orcid":false,"given":"Han","family":"Wu","sequence":"first","affiliation":[{"name":"The Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College)  Hangzhou 310014 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