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Clinical treatments through frequent antibiotics administration and surgical debridement bring inevitable side effects including drug\u2010resistance and disfigurements. It is urgent to develop an antibiotics\u2010free and rapid strategy to treat osteomyelitis. Herein, a bifunctional sonosensitizer that consists of porphyrin\u2010like Zn single\u2010atom catalysts (g\u2010ZnN<jats:sub>4<\/jats:sub>) and MoS<jats:sub>2<\/jats:sub> quantum dots is developed, which exhibits excellent sonodynamic antibacterial efficiency and osteogenic ability. It is found that the construction of heterogeneous interfaces of g\u2010ZnN<jats:sub>4<\/jats:sub>\u2010MoS<jats:sub>2<\/jats:sub> fully activates the adsorbed O<jats:sub>2<\/jats:sub> due to the increased interface charge transfer, enhanced spin\u2212flip, and reduced activation energy of O<jats:sub>2<\/jats:sub>. The generated <jats:sup>1<\/jats:sup>O<jats:sub>2<\/jats:sub> can kill methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) with an antibacterial efficiency of 99.58% under 20\u00a0min of ultrasound (US) irradiation. The Zn single atoms immobilized in g\u2010ZnN<jats:sub>4<\/jats:sub> can be released steadily in the form of Zn<jats:sup>2+<\/jats:sup> for 28 days within safe concentration, realizing the great osteoinductive ability of such a sonosensitizer. For the treatment of MRSA\u2010infected osteomyelitis, the inflammation and bone loss can be significantly suppressed through sonodynamic ion therapy. This work provides another strategy for developing high efficiency sonosensitizer through ultrasound interfacial engineering.<\/jats:p>","DOI":"10.1002\/smll.202105775","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T10:28:33Z","timestamp":1639132113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Ultrasonic Interfacial Engineering of MoS<sub>2<\/sub>\u2010Modified Zn Single\u2010Atom Catalysts for Efficient Osteomyelitis Sonodynamic Ion Therapy"],"prefix":"10.1002","volume":"18","author":[{"given":"Xiaobo","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan 430022 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Union Hospital 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