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However, antibody\u2010mediated rejection (ABMR) threatens long\u2010term survival of renal grafts. Although ABMR can be controlled by donor\u2010specific antibody clearance and B\u2010 or (and) plasma\u2010cells inhibition, the treatment often causes severe side effects in patients. Therefore, there is need to explore site\u2010specific scavengers. In this study, a nanovehicle carrying an anti\u2010inflammatory drug is developed with complement component 4d targeting, a specific biomarker expressed on allograft endothelium under ABMR. Moreover, the nanovehicle is endowed with photothermal properties to control drug release. Analysis through systematic in vitro and in vivo toxicity, non\u2010invasive targeted imaging, and in situ remote controlled drug release show the nanovehicle specifically targets allograft kidney endothelium, releases an anti\u2010inflammatory drug, methylprednisolone, locally upon laser irradiation, and promotes recovery of injured endothelium, without affecting systemic inflammation or innate immune responses. This strategy has the potential for future clinical application in ABMR treatment.<\/jats:p>","DOI":"10.1002\/smll.202106746","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T14:15:11Z","timestamp":1646230511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Vivo Kidney Allograft Endothelial Specific Scavengers for On\u2010Site Inflammation Reduction under Antibody\u2010Mediated Rejection"],"prefix":"10.1002","volume":"18","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou 310003 China"},{"name":"Pharmaceutical Sciences Laboratory \u00c5bo Akademi University  Turku 20520 Finland"},{"name":"Turku Bioscience Centre University of Turku and \u00c5bo Akademi University  Turku 20520 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengpeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou 310003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory \u00c5bo Akademi University  Turku 20520 Finland"},{"name":"Turku Bioscience Centre University of Turku and \u00c5bo Akademi University  Turku 20520 Finland"},{"name":"ENT institute and Department of Otorhinolaryngology Eye &amp; ENT Hospital State Key Laboratory of Medical Neurobiology Institutes of Biomedical Sciences Fudan University  Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory \u00c5bo Akademi University  Turku 20520 Finland"},{"name":"Turku Bioscience Centre University of Turku and \u00c5bo Akademi University  Turku 20520 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhayakumar Rajan","family":"Prakash","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory \u00c5bo Akademi University  Turku 20520 Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine Zhejiang University  Hangzhou Zhejiang Province 310029 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junnian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Experimental Hematology and Biochemistry Lab Beijing Institute of Radiation Medicine  Beijing 100850 China"},{"name":"Stem Cell and Regenerative Medicine Lab Institute of Health Service and Transfusion Medicine  Beijing 100850 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rending","family":"Wang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou 310003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou 310003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou 310003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-4416","authenticated-orcid":false,"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory \u00c5bo Akademi University  Turku 20520 Finland"},{"name":"Turku Bioscience Centre University of Turku and \u00c5bo Akademi University  Turku 20520 Finland"},{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 200025 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Shen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center The First Affiliated Hospital College of Medicine Zhejiang University  Hangzhou 310003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_1_1","DOI":"10.2471\/BLT.17.206441"},{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/j.trre.2016.10.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_2_2","DOI":"10.1056\/NEJMra0902927"},{"key":"e_1_2_8_2_3","first-page":"1601","volume":"32","author":"Bamoulid J.","year":"2017","journal-title":"Nephrol. 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