{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:16:51Z","timestamp":1790554611102,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21674054"],"award-info":[{"award-number":["21674054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073153"],"award-info":[{"award-number":["52073153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51722302"],"award-info":[{"award-number":["51722302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019JQ17"],"award-info":[{"award-number":["ZR2019JQ17"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The preparation of a type of innovative cationic copolypeptoid antimicrobials containing various hydrophobic moieties that resemble both structure and membrane\u2010lytic antibacterial mechanism of natural antimicrobial peptides (AMPs) is reported. By finely tuning the hydrophilic\/hydrophobic balance, the polypeptoids exhibit a wide spectrum of antibacterial activity against both Gram\u2010positive bacteria and Gram\u2010negative bacteria with the lowest minimum inhibitory concentration (MIC) at only 2 \u00b5g mL<jats:sup>\u22121<\/jats:sup>, whereas they also show low haemolytic properties. In particular, high selectivity (&gt;128) is achieved from the polymers with butyl moieties. Moreover, the polypeptoids can readily inhibit the formation of biofilms and effectively eradicate the bacteria embedded in the mature biofilms, which is superior to many natural AMPs and vancomycin. Unlike conventional antibiotics, the polypeptoids possess potent activity against drug\u2010resistant bacteria without visible resistance development after repeated usage. Notably, the polypeptoid antimicrobials not only have inherently fast bactericidal properties and excellent stability against incubation with human plasma, but also show excellent in vivo antibacterial effect. The prepared antimicrobials, coated onto magnetic nanospheres show recycling properties and enhanced antibacterial activity as combined with near\u2010infrared (NIR)\u2010induced photothermal antibacterial therapy.<\/jats:p>","DOI":"10.1002\/smll.202106936","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T08:45:29Z","timestamp":1644482729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Antibacterial Copolypeptoids with Potent Activity against Drug Resistant Bacteria and Biofilms, Excellent Stability, and Recycling Property"],"prefix":"10.1002","volume":"18","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"},{"name":"Key Laboratory of Biobased Polymer Materials College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Science Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhe","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Qilu Hospital of Shandong University  Jinan 250000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutao","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biobased Polymer Materials College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao 266042 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Life Science Qingdao University  Qingdao 266071 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1267-0215","authenticated-orcid":false,"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University  Changchun 130012 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70799-6"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.3.280"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf811"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201802140"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.09.018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M600334-MCP200"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337927"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1441"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph6121543"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1098"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.03.030"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2008.10.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(99)00197-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12223-013-0280-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.12.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20252"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-4-731"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04051"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9070599"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-010-2920-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914304"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03325-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja500367u"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00469-17"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00179"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26221-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma202319g"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00201"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201702624"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201500275"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC04704J"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600381"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc300091d"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma201948u"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2014.08.028"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.8b02230"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja907380d"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma401067f"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc33881e"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma302412v"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b01014"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.8b00986"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2018.01.034"},{"key":"e_1_2_7_45_1","first-page":"201","volume":"1","author":"Manuel N. M.","year":"2006","journal-title":"Recent Pat. Anti\u2010Infect. Drug Discovery"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/35007145"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708254105"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813810"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176667"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402254"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01330"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01516-10"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12702-8"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjm-2015-0855"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn513"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-08241-3"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM00248K"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.02.008"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202000505"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01579544"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.100.3.965"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002030050681"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3317-3321.2000"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.559"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201507567"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.321.5887.356"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2012.02528.x"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00648E"},{"key":"e_1_2_7_69_1","doi-asserted-by":"crossref","unstructured":"F.Guilhelmelli N.Vilela P.Albuquerque L.Derengowski I.Silva\u2010Pereira C.Kyaw 2013 4 353.","DOI":"10.3389\/fmicb.2013.00353"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.2"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph8030366"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.06.067"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202106936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202106936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202106936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:11:27Z","timestamp":1693109487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202106936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,10]]},"references-count":72,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/smll.202106936"],"URL":"https:\/\/doi.org\/10.1002\/smll.202106936","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,10]]},"assertion":[{"value":"2021-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2106936"}}