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Glucose\u2010activated cascade reactions can consume glucose and eradicate bacteria, avoiding the direct use of hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) and wound pH restriction on peroxidase\u2010like activity. However, the anoxic microenvironment in diabetic wounds impedes the cascade reaction due to the oxygen (O<jats:sub>2<\/jats:sub>) dependence of glucose oxidation. Herein, defect\u2010rich molybdenum disulfide nanosheets loaded with bovine serum albumin\u2010modified gold nanoparticle (MoS<jats:sub>2<\/jats:sub>@Au@BSA NSs) heterostructures are designed and anchored onto injectable hydrogels to promote diabetic wound healing through an O<jats:sub>2<\/jats:sub> self\u2010supplying cascade reaction. BSA decoration decreases the particle size of Au, increasing the activity of multiple enzymes. Glucose oxidase\u2010like Au catalyzes the oxidation of glucose into gluconic acid and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, which is transformed into a hydroxyl radical (\u2022OH) catalyzed by peroxidase\u2010like MoS<jats:sub>2<\/jats:sub>@Au@BSA to eradicate bacteria. When the wound pH reaches an alkalescent condition, MoS<jats:sub>2<\/jats:sub>@Au@BSA mimicks superoxide dismutase to transform superoxide anions into O<jats:sub>2<\/jats:sub> and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, and decomposes endogenous and exogenous H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> into O<jats:sub>2<\/jats:sub> via catalase\u2010like mechanisms, reducing oxidative stress, alleviating hypoxia, and facilitating glucose oxidation. The MoS<jats:sub>2<\/jats:sub>@Au@BSA nanozyme\u2010anchored injectable hydrogel, composed of oxidized dextran and glycol chitosan crosslinked through a Schiff base, significantly accelerates diabetic wound healing.<\/jats:p>","DOI":"10.1002\/smll.202200165","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T06:49:26Z","timestamp":1649054966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Injectable Hydrogel Based on Defect\u2010Rich Multi\u2010Nanozymes for Diabetic Wound Healing via an Oxygen Self\u2010Supplying Cascade Reaction"],"prefix":"10.1002","volume":"18","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"Shaanxi Key Laboratory of Degradable Biomedical Materials School of Chemical Engineering Northwest University  Xi'an Shaanxi 710069 China"},{"name":"Shaanxi R&amp;D Centre of Biomaterials and Fermentation Engineering School of Chemical Engineering Northwest University  Xi'an Shaanxi 710069 China"},{"name":"Biotech. and Biomed. 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