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In this study, it is shown that MSC\u2010derived apoptotic vesicles (apoVs) can ameliorate multiple organ dysfunction and improve survival in septic mice. Mechanistically, it is found that tail vein\u2010infused apoVs mainly accumulate in the bone marrow of septic mice via electrostatic charge interactions with positively charged neutrophil extracellular traps (NETs). Moreover, apoVs switch neutrophils NETosis to apoptosis via the apoV\u2010Fas ligand (FasL)\u2010activated Fas pathway. In summary, these findings uncover a previously unknown role of apoVs in sepsis treatment and an electrostatic charge\u2010directed target therapeutic mechanism, suggesting that cell death is associated with disease development and therapy.<\/jats:p>","DOI":"10.1002\/smll.202200306","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T01:09:50Z","timestamp":1650071390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Electrostatic Charge\u2010Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis"],"prefix":"10.1002","volume":"18","author":[{"given":"Qianmin","family":"Ou","sequence":"first","affiliation":[{"name":"South China Center of Craniofacial Stem Cell Research Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010Sen University  Guangzhou 510080 P. R. 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