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In this study, a new class of materials, that is, polymeric amines including polyethyleneimine (PEI), poly\u2010L\u2010lysine, and poly(allylamine hydrochloride), is discovered to induce NO generation from\n                    <jats:italic>S<\/jats:italic>\n                    \u2010nitrosothiols (RSNOs) at physiological conditions. Controlled NO generation can be readily achieved by tuning the concentration of the NO donors (RSNOs) and polymers, and the type and molecular weight of the polymers. Importantly, the mechanism of NO generation by these polymers is deciphered to be attributed to the nucleophilic reaction between primary amines on polymers and the SNO groups of RSNOs. The NO\u2010releasing feature of the polymers can be integrated into a suite of materials, for example, simply by embedding PEI into poly(vinyl alcohol) (PVA) hydrogels. The functionality of the PVA\/PEI hydrogels is demonstrated for\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    biofilm prevention with a\n                    <jats:bold>\u2248<\/jats:bold>\n                    4\u00a0log reduction within 6\u00a0h. As NO has potential therapeutic implications in various diseases, the identification of polymeric amines to induce NO release will open new opportunities in NO\u2010generating biomaterials for antibacterial, antiviral, anticancer, antithrombotic, and wound healing applications.\n                  <\/jats:p>","DOI":"10.1002\/smll.202200502","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T07:11:33Z","timestamp":1657005093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Polymeric Amines Induce Nitric Oxide Release from\n                    <i>S<\/i>\n                    \u2010Nitrosothiols"],"prefix":"10.1002","volume":"19","author":[{"given":"Zijie","family":"Luo","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gervase","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"},{"name":"Cluster for Advanced Macromolecular Design (CAMD) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhu","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Boyer","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"},{"name":"Cluster for Advanced Macromolecular Design (CAMD) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-8844","authenticated-orcid":false,"given":"Rona","family":"Chandrawati","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney)  Sydney NSW 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2214"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4623"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003895"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/B912493B"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15273h"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805818"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2020.100887"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201800155"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15272j"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201701043"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00486"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01197E"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.02.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/am402618w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn700191f"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB00299A"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.015"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01411"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000248"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.1c01121"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01685"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.12.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201907635"},{"key":"e_1_2_8_24_1","first-page":"486","author":"Thai J. 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