{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:00:32Z","timestamp":1780387232463,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101099"],"award-info":[{"award-number":["82101099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970778"],"award-info":[{"award-number":["81970778"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Posterior capsular opacification (PCO) is the leading complication after cataract surgery, and is mainly induced by the proliferation and migration of residual lens epithelial cells (LECs). Although numerous attempts have been made to reduce the incidence of PCO, this complication remains a critical challenge in postoperative visual recovery. This study aims to report a functionalized intraocular lens (R\u2010IOL) with a region\u2010confined photothermal effect for the active prevention of PCO after implantation. The outer rim of R\u2010IOL (non\u2010optical area) is decorated with a nanoporous gold (NPG) ring, which can effectively eliminate the LECs around R\u2010IOL, ultimately inhibiting the migration of LECs from the periphery to the visual axis center in the initial stage, and preventing the subsequent PCO. Furthermore, the mechanism of LECs elimination can be attributed to apoptosis induced by mild photothermal therapy. After in vivo implantation for 30 days, PCO is rarely observed in the R\u2010IOL group, whereas the considerably higher incidence of PCO (75%) is found in the pristine IOL (P\u2010IOL) group. The region\u2010confined photothermal effect based on NPG not only provides an active strategy to effectively prevent PCO, but also introduces new opportunities for the treatment of undesirable hyperplasia.<\/jats:p>","DOI":"10.1002\/smll.202201098","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T04:51:15Z","timestamp":1657169475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nanoporous Gold Ring\u2010Integrated Photothermal Intraocular Lens for Active Prevention of Posterior Capsular Opacification"],"prefix":"10.1002","volume":"18","author":[{"given":"Dong","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianni","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanmao","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology The First Affiliated Hospital of Sun Yat\u2010sen University Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology The First Affiliated Hospital of Sun Yat\u2010sen University Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010jiuan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information Technology The First Affiliated Hospital of Sun Yat\u2010sen University Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3023-4057","authenticated-orcid":false,"given":"Weirong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat\u2010sen University  Guangzhou 510060 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30544-5"},{"key":"e_1_2_7_2_1","first-page":"2079","volume":"60","author":"Zhang L.","year":"2019","journal-title":"Invest. 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