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Benefiting from the excellent anti\u2010biofouling property of zwitterionic materials and their successful application in macroscopic implanted devices, microcapsules with zwitterionic coatings may be promising candidates for islet encapsulation. Herein, a series of zwitterion\u2010coated core\u2013shell microcapsules is fabricated (including carboxybetaine methacrylate [CBMA]\u2010coated gelatin methacrylate [GelMA] [CBMA\u2010GelMA], sulfobetaine methacrylate [SBMA]\u2010coated GelMA [SBMA\u2010GelMA], and phosphorylcholine methacrylate [MPC]\u2010coated GelMA [MPC\u2010GelMA]) by one\u2010step photopolymerization of inner GelMA and outer zwitterionic monomers via a handmade two\u2010fluid microfluidic device and it is demonstrated\u00a0that they can effectively prevent protein adsorption, cell adhesion, and inflammation in vitro. Interestingly, the zwitterionic microcapsules successfully resist FBR in C57BL\/6 mice after intraperitoneal implantation for up to 4 months. After successfully encapsulating xenogeneic rat islets in the SBMA\u2010GelMA microcapsules, sustained normoglycemia is further validated in streptozotocin (STZ)\u2010induced mice for up to 3 months. The zwitterion\u2010modified microcapsule using a microfluidic device may represent a platform for cell encapsulation treatment for T1DM and other hormone\u2010deficient diseases.<\/jats:p>","DOI":"10.1002\/smll.202202596","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T03:04:07Z","timestamp":1655953447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation"],"prefix":"10.1002","volume":"18","author":[{"given":"Zhisheng","family":"Xiao","sequence":"first","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon\u2010Based Functional Materials and Devices Soochow University  Suzhou 215123 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