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Nitinol (Ni\u2013Ti) stents, a standard treatment for prolonging patients\u2019 lives, are susceptible to reocclusion and cannot inhibit tumor recurrence because they lack antitumor and antibacterial activity. Herein, an arsenic\u2010loaded layered double\u2010hydroxide film is constructed on Ni\u2013Ti, forming a micro \u201cchemical factory.\u201d The LDH plays the role of a \u201cprocesser\u201d which absorbs highly toxic trivalent arsenic (As(III)) and processes it into lowly toxic pentavalent arsenic (As(V)). It also acts as a \u201cquality\u2010inspector,\u201d confining As(III) in the interlayer and releasing only As(V) (the finished product) to the outside. This control mechanism minimizes the toxicity during contact with normal tissue. The acidic microenvironment and overexpression of glutathione in tumor tissues not only accelerates the release of arsenic from the platform but also triggers the in situ transformation of arsenic from lowly toxic As(V) to highly toxic As(III), exerting a strong arsenic\u2010mediated antineoplastic effect. Such a microenvironment\u2010responsive \u201cchemical factory\u201d with arsenic processing and screening functions is expected to prevent tumor overgrowth, metastasis, and bacterial infection and provide new insights into the design of Ni\u2013Ti drug\u2010eluting stents for gallbladder cancer treatment.<\/jats:p>","DOI":"10.1002\/smll.202202908","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T01:30:06Z","timestamp":1661477406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Layered Double Hydroxide\u2010Based Micro \u201cChemical Factory\u201d with Arsenic Processing and Screening Functions on Nitinol for Gallbladder Cancer Treatment"],"prefix":"10.1002","volume":"18","author":[{"given":"Shun","family":"Xing","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Biomedical Engineering Hebei University of Technology Tianjin 300130 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Peng","sequence":"additional","affiliation":[{"name":"Medical Research Center Department of Orthopedics Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naijian","family":"Ge","sequence":"additional","affiliation":[{"name":"Intervention Center Eastern Hepatobiliary Surgery Hospital The Third Affiliated Hospital of Naval Medical University Shanghai 200438 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-8143","authenticated-orcid":false,"given":"Xuanyong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2021200087"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83924-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20200726"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-34244-3_6"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11815"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.27193"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_8_9_1","first-page":"249","volume":"59","author":"Liu Y. 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