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Nanogels, with the advantages of both hydrogels and nanoparticles, may hold potential for addressing the above issue. Here, a dual\u2010responsive nanogel platform (HPC nanogel) is constructed using \u03b2\u2010cyclodextrin\u2010conjugated hyaluronic acid (HA\u2010\u03b2CD), polyethyleneimine (PEI), and cisplatin. HA\u2010\u03b2CD and PEI compose the skeleton of the nanogel, and cisplatin molecules provide the junctions inside the skeleton, thus affording a multiple interactions\u2010based nanogel. Besides, HA endows the nanogel with hyaluronidase (HAase)\u2010responsiveness, and cisplatin guarantees the glutathione (GSH)\u2010responsive ability, which make the nanogel a dual\u2010responsive platform that can degrade and release the loaded drugs when encountering HAase or GSH. Additionally, the HPC nanogel possesses excellent small\u2010molecule drug and protein loading and intracellular delivery capabilities. Especially, for proteins, their intracellular delivery via nanogels is not hindered by serum proteins, and the enzymes delivered into cells still maintain their catalytic activities. Furthermore, the nanogel can codeliver different cargoes to achieve \u201ccocktail\u201d chemotherapeutic efficacy and realize combination cancer therapy. Overall, the HPC nanogel can serve as a multifunctional platform capable of delivering desired drugs to treat cancer or other diseases.<\/jats:p>","DOI":"10.1002\/smll.202203260","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T02:31:20Z","timestamp":1667615480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Platinum\u2010Coordinated Dual\u2010Responsive Nanogels for Universal Drug Delivery and Combination Cancer Therapy"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-6202","authenticated-orcid":false,"given":"Qiu\u2010Yi","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University  2 Sipailou Road Nanjing 210096 P. R. 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