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To date, biofabricated vascular models have not yet realized four fundamental attributes of native vasculatures simultaneously: freestanding, branching, multilayered, and perfusable. In this work, a microfluidics\u2010enabled molding technique combined with coaxial bioprinting to fabricate anatomically relevant, cell\u2010laden vascular models consisting of hydrogels is developed. By using 3D porous molds of poly(ethylene glycol) diacrylate as casting templates that gradually release calcium ions as a crosslinking agent, freestanding, and perfusable vascular constructs of complex geometries are fabricated. The bioinks can be tailored to improve the compatibility with specific vascular cells and to tune the mechanical modulus mimicking native blood vessels. Crucially, the integration of relevant vascular cells (such as smooth muscle cells and endothelial cells) in a multilayer and biomimetic configuration is highlighted. It is also demonstrated that the fabricated freestanding vessels are amenable for testing percutaneous coronary interventions (i.e., drug\u2010eluting balloons and stents) under physiological mechanical states such as stretching and bending. Overall, a versatile fabrication technique with multifaceted possibilities of generating biomimetic vascular models that can benefit future research in mechanistic understanding of cardiovascular diseases and the development of therapeutic interventions is introduced.<\/jats:p>","DOI":"10.1002\/smll.202203426","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T05:42:50Z","timestamp":1658468570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biomimetic Vasculatures by 3D\u2010Printed Porous Molds"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2020","authenticated-orcid":false,"given":"Terry","family":"Ching","sequence":"first","affiliation":[{"name":"Pillar of Engineering Product Development Singapore University of Technology and Design  8 Somapah Rd Singapore 487372 Singapore"},{"name":"Digital Manufacturing and Design Centre 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