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Herein, hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    )\/ultrasound (US)\u2010driven mesoporous manganese oxide (MnO\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    )\u2010based nanomotors are constructed by loading mitochondrial sonosensitizers into their mesoporous channels and orderly dual\u2010functionalizing their surface with silk fibroin and chondroitin sulfate. The locomotory activities and tumor\u2010targeting capacities of the resultant nanomotors (CS\u2010ID@NMs) are greatly improved in the presence of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and US irradiation, inducing efficient mucus\u2010traversing and deep tumor penetration. The excess H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    in the tumor microenvironment (TME) is decomposed into hydroxyl radicals and oxygen by an Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated Fenton\u2010like reaction, and the produced oxygen participates in sonodynamic therapy (SDT), yielding abundant singlet oxygen. The combined Mn\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010mediated chemodynamic therapy and SDT cause effective ferropotosis of tumor cells and accelerate the release of tumor antigens. Importantly, animal experiments reveal that the treatment of combining oral hydrogel (chitosan\/alginate)\u2010embedding CS\u2010ID@NMs and immune checkpoint inhibitors can simultaneously suppress the growth of primary and distal tumors through direct killing, reversion of immunosuppressive TME, and potentiation of systemic anti\u2010tumor immunity, demonstrating that the CS\u2010ID@NM\u2010based platform is a robust oral system for synergistic treatment of colon cancer.\n                  <\/jats:p>","DOI":"10.1002\/smll.202203466","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T22:00:56Z","timestamp":1663538456000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Oral Nanomotor\u2010Enabled Mucus Traverse and Tumor Penetration for Targeted Chemo\u2010Sono\u2010Immunotherapy against Colon 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