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To tackle the daunting issue, a bioheterojunction\u2010engineered orthopedic polyetheretherketone (PEEK) implant consisting of copper sulfide\/graphene oxide (CuS\/GO) bioheterojunctions (bioHJs) and glucose oxidase (GO<jats:italic>x<\/jats:italic>) is conceived and developed for DIM enhanced disinfection and boosted osseointegration. Under hyperglycemic micromilieu, GO<jats:italic>x<\/jats:italic> can convert surrounding glucose into hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>). Then, upon infectious micromilieu, the bioHJs enable the catalyzation of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> to highly germicidal hydroxyl radical (\u00b7OH). As a result, the engineered implants massacre pathogenic bacteria through DIM twin\u2010engine powered photo\u2010chemodynamic therapy in vitro and in vivo. In addition, the engineered implants considerably facilitate cell viability and osteogenic activity of osteoblasts under a hyperglycemic microenvironment via synergistic induction of copper ions (Cu<jats:sup>2+<\/jats:sup>) and GO. In vivo studies using bone defect models of diabetic rats at 4 and 8 weeks further authenticate that bioHJ\u2010engineering PEEK implants substantially elevate their osseointegration through biofilm elimination and vascularization, as well as macrophage reprogramming. Altogether, the present study puts forward a tactic that arms orthopedic implants with DIM twin\u2010engine powered antibacterial and formidable osteogenic capacities for diabetic stalled osseointegration.<\/jats:p>","DOI":"10.1002\/smll.202203619","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T21:43:40Z","timestamp":1662759820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Bioheterojunction\u2010Engineered Polyetheretherketone Implants With Diabetic Infectious Micromilieu Twin\u2010Engine Powered Disinfection for Boosted Osteogenicity"],"prefix":"10.1002","volume":"18","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering School of Chemical Engineering West China Hospital of Stomatology State Key Laboratory of Oral Diseases Sichuan University  Chengdu 610065 P. R. 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