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Here, scavenger magnetic nanoparticles enveloped by nanovesicles derived from blood cells (MNVs) are reported, which magnetically eradicate an extreme range of pathogens in an extracorporeal circuit. It is quantitatively revealed that glycophorin A and complement receptor (CR) 1 on red blood cell (RBC)\u2010MNVs predominantly capture human fecal bacteria, carbapenem\u2010resistant (CR)\n                    <jats:italic>Escherichia\u00a0 coli<\/jats:italic>\n                    , and extended\u2010spectrum beta\u2010lactamases\u2010positive (ESBL\u2010positive)\n                    <jats:italic>E. coli<\/jats:italic>\n                    , vancomycin\u2010intermediate\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (VISA), endotoxins, and proinflammatory cytokines in human blood. Additionally, CR3 and CR1 on white blood cell\u2010MNVs mainly contribute to depleting the virus envelope proteins of Zika, SARS\u2010CoV\u20102, and their variants in human blood. Supplementing opsonins into the blood significantly augments the pathogen removal efficiency due to its combinatorial interactions between pathogens and CR1 and CR3 on MNVs. The extracorporeal blood cleansing enables full recovery of lethally infected rodent animals within 7 days\u00a0by treating them twice in series. It is also validated that parameters reflecting immune homeostasis, such as blood cell counts, cytokine levels, and transcriptomics changes, are restored in blood of the fatally infected rats after treatment.\n                  <\/jats:p>","DOI":"10.1002\/smll.202203746","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T14:29:57Z","timestamp":1662560997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human Cell\u2010Camouflaged Nanomagnetic Scavengers Restore Immune Homeostasis in a Rodent Model with Bacteremia"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1476-9940","authenticated-orcid":false,"given":"Sung Jin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST) UNIST gil 50 Ulsan 44919 Republic of 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