{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:01:15Z","timestamp":1793120475605,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"46","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Building medical microrobots from the body's own cells may circumvent the biocompatibility concern and hence presents more potential in clinical applications to improve the possibility of escaping from the host defense mechanism. More importantly, live cells can enable therapeutically relevant functions with significantly higher efficiency than synthetic systems. Here, live immune cell\u2010derived microrobots from macrophages,\u00a0i.e.,\u00a0\n                    <jats:italic>immunobots<\/jats:italic>\n                    , which can be remotely steered with externally applied magnetic fields and directed toward anti\u2010tumorigenic (M1) phenotypes, are presented. Macrophages engulf the engineered\u00a0\n                    <jats:italic>magnetic decoy bacteria<\/jats:italic>\n                    , composed of 0.5\u00a0\u00b5m diameter silica Janus particles with one side coated with anisotropic FePt magnetic nanofilm and the other side coated with bacterial lipopolysaccharide (LPS). This study demonstrates the torque\u2010based surface rolling locomotion of the immunobots along assigned trajectories inside blood plasma, over a layer of endothelial cells, and under physiologically relevant flow rates. The immunobots secrete signature M1 cytokines, IL\u201012 p40, TNF\u2010\u03b1, and IL\u20106, and M1 cell markers, CD80 and iNOS, via toll\u2010like receptor 4 (TLR4)\u2010mediated stimulation with bacterial LPS. The immunobots exhibit anticancer activity against urinary bladder cancer cells. This study further demonstrates such immunobots from freshly isolated primary bone marrow\u2010derived macrophages since patient\u2010derivable macrophages may have a strong clinical potential for future cell therapies in cancer.\n                  <\/jats:p>","DOI":"10.1002\/smll.202204016","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T21:55:37Z","timestamp":1665093337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Remotely Guided Immunobots Engaged in Anti\u2010Tumorigenic Phenotypes for Targeted Cancer Immunotherapy"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-2943","authenticated-orcid":false,"given":"Nihal Olcay","family":"Dogan","sequence":"first","affiliation":[{"name":"Physical Intelligence Department Max Planck Institute for Intelligent Systems  70569 Stuttgart Germany"},{"name":"Institute for Biomedical 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