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The secreted FST protein, endogenously synthesized from delivered mRNA, efficiently reduces elevated activin A levels associated with aggressive ovarian cancer and associated cachexia. By altering the cancer cell phenotype, mRNA treatment prevents malignant ascites, delays cancer progression, induces the formation of solid tumors, and preserves muscle mass in cancer\u2010bearing mice by inhibiting negative regulators of muscle mass. Finally, mRNA therapy provides synergistic effects in combination with cisplatin, increasing the survival of mice and counteracting muscle atrophy induced by chemotherapy and cancer\u2010associated cachexia. The treated mice develop few nonadherent tumors that are easily resected from the peritoneum. Clinically, this nanomedicine\u2010based mRNA therapy can facilitate complete cytoreduction, target resistance, improve resilience during aggressive chemotherapy, and improve survival in advanced ovarian cancer.<\/jats:p>","DOI":"10.1002\/smll.202204436","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T10:44:03Z","timestamp":1663065843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Nanoparticle\u2010Based Follistatin Messenger RNA Therapy for Reprogramming Metastatic Ovarian Cancer and Ameliorating Cancer\u2010Associated Cachexia"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-2778","authenticated-orcid":false,"given":"Tetiana","family":"Korzun","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Oregon State University  2730 S Moody Avenue Portland OR 97201 USA"},{"name":"Department of Biomedical Engineering Oregon Health &amp; 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