{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:32:25Z","timestamp":1792067545552,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81821002"],"award-info":[{"award-number":["81821002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790251"],"award-info":[{"award-number":["81790251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130082"],"award-info":[{"award-number":["82130082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["202003N4247"],"award-info":[{"award-number":["202003N4247"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chemo\u2010phototherapy has emerged as a promising approach to complement traditional cancer treatment and enhance therapeutic effects. However, it still faces the challenges of drug efflux transporter\u2010mediated chemoresistance and heat shock proteins (HSPs)\u2010mediated phototherapy tolerance, which both depend on an excessive supply of adenosine triphosphate. Therefore, manipulating energy metabolism to impair the expression or function of P\u2010glycoprotein (P\u2010gp) and HSPs may be a prospective strategy to reverse cancer therapeutic resistance. Herein, a chondroitin sulfate (CS)\u2010functionalized zeolitic imidazolate framework\u20108 (ZIF\u20108) chemo\u2010phototherapy nanoplatform (CS\/ZIF\u20108@A780\/DOX NPs) is rationally designed that is capable of manipulating energy metabolism against cancer therapeutic resistance by integrating the photosensitizer IR780\u00a0iodide (IR780)\u2010conjugated atovaquone (ATO) (A780) and the chemotherapeutic agent doxorubicin (DOX). Mechanistically, ATO and zinc ions that are released in the acidic tumor microenvironment can lead to systematic energy exhaustion through disturbing mitochondrial electron transport and the glycolysis process, thus suppressing the activity of P\u2010gp and HSP70, respectively. In addition, CS is used on the surface of ZIF\u20108@A780\/DOX NPs to improve the targeting capability to tumor tissues. These data provide an efficient strategy for manipulating energy metabolism for cancer treatment, especially for overcoming cancer chemo\u2010phototherapy resistance.<\/jats:p>","DOI":"10.1002\/smll.202204926","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T20:00:43Z","timestamp":1666209643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Nanoengineering a Zeolitic Imidazolate Framework\u20108 Capable of Manipulating Energy Metabolism against Cancer Chemo\u2010Phototherapy Resistance"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4469-6666","authenticated-orcid":false,"given":"Shuaijun","family":"Lu","sequence":"first","affiliation":[{"name":"The Affiliated Hospital of Medical School Ningbo University  Ningbo 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine  Chengdu 611137 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Medical School Ningbo University  Ningbo 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Wang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Medical School Ningbo University  Ningbo 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard C.","family":"Nice","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Monash University  Clayton VIC 3800 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhua","family":"Huang","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Medical School Ningbo University  Ningbo 315020 China"},{"name":"State Key Laboratory of Biotherapy and Cancer Center, and Collaborative Innovation Center for Biotherapy West China Hospital West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-0990","authenticated-orcid":false,"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Medical School Ningbo University  Ningbo 315020 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202007761"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201801022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03473-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100289"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1730-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2020.100720"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2021.188623"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0005-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207213"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121621"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101267"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100978"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4128"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-017-2220-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.10.095"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103534"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.134781"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b04166"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01320-5"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02372-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b13487"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114380"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS01074C"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105274"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.06.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR08442D"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa043"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.06.023"},{"key":"e_1_2_9_29_1","first-page":"4273261","volume":"2019","author":"Ye N.","year":"2019","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201038"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01082-3"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02782"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202114903"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00779"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.022"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.09.049"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2020.12.028"}],"container-title":["Small"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202204926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/smll.202204926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smll.202204926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:19:07Z","timestamp":1692663547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202204926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":37,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/smll.202204926"],"URL":"https:\/\/doi.org\/10.1002\/smll.202204926","archive":["Portico"],"relation":{},"ISSN":["1613-6810","1613-6829"],"issn-type":[{"value":"1613-6810","type":"print"},{"value":"1613-6829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,19]]},"assertion":[{"value":"2022-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2204926"}}