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Herein, antibiotic\u2010loaded mesoporous nanozymes (HA@MRuO<jats:sub>2<\/jats:sub>\u2010Cip\/GOx) are fabricated for overcoming bacterial resistance, and activating the local immunosuppression in biofilm microenvironment (BME). HA@MRuO<jats:sub>2<\/jats:sub>\u2010Cip\/GOx are prepared by physical adsorption between ciprofloxacin (Cip) or glucose oxidase (GOx) and MRuO<jats:sub>2<\/jats:sub> NPs, and modified with hyaluronic acid (HA). In vitro, HA@MRuO<jats:sub>2<\/jats:sub>\u2010Cip\/GOx cleaves extracellular DNA (eDNA) to disrupt biofilm, thereby enhancing Cip kill planktonic bacteria. Furthermore, HA@MRuO<jats:sub>2<\/jats:sub>\u2010Cip\/GOx can induce polarization and enhance phagocytosis of a macrophage\u2010derived cell line. More importantly, in vivo therapeutic performance confirms that HA@MRuO<jats:sub>2<\/jats:sub>\u2010Cip\/GOx can trigger macrophage\u2010related immunity, and effectively alleviate MRSA\u2010bacterial lung infections. Accordingly, nanocatalytic therapy combined with targeted delivery of antibiotics could enhance the treatment of bacterial infections.<\/jats:p>","DOI":"10.1002\/smll.202204928","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T02:15:58Z","timestamp":1672625758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Macrophage Polarization Induced by Bacteria\u2010Responsive Antibiotic\u2010Loaded Nanozymes for Multidrug Resistance\u2010Bacterial Infections Management"],"prefix":"10.1002","volume":"19","author":[{"given":"Xufeng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Chemistry and Materials Jinan University  Guangzhou 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Chemistry and Materials Jinan University  Guangzhou 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Chemistry and Materials Jinan University  Guangzhou 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2237-9309","authenticated-orcid":false,"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Chemistry and Materials Jinan University  Guangzhou 511436 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.133"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.99"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1318"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4000"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature.2017.21550"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c00269"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0019-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.6339-6345.2002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-018-9501-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201605296"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1758"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09973"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201908783"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006772"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202008720"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.06.073"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c05255"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200255"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119848"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00861"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01707-20"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2004.01.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b00087"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0672-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb9011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02666-16"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02291-18"},{"key":"e_1_2_8_30_1","volume":"64","author":"Asempa T. 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