{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:30:52Z","timestamp":1792031452992,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"47","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["818731226"],"award-info":[{"award-number":["818731226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Timely restoration of blood supply after myocardial ischemia is imperative for the treatment of acute myocardial infarction but causes additional myocardial ischemia\/reperfusion (MI\/R) injury, which has not been hitherto effectively targeted by interventions for MI\/R injury. Hence, the development of advanced nanomedicine that can reduce apoptosis of cardiomyocytes while protecting against MI\/R in vivo is of utmost importance. Herein, a redox\u2010responsive and emissive TPE\u2010ss covalent organic framework (COF) nanocarrier by integrating aggregation\u2010induced emission luminogens and redox\u2010responsive disulfide motifs into the COF skeleton is developed. TPE\u2010ss COF allows for efficient loading and delivery of matrine, a renowned anti\u2010cryptosporidial drug, which significantly reduces MI\/R\u2010induced functional deterioration and cardiomyocyte injury when injected through the tail vein into MI\/R models at 5\u00a0min after 30\u00a0min of ischemia. Moreover, TPE\u2010ss COF@Matrine shows a drastic reduction in cardiomyocyte apoptosis and improvements in cardiac function and survival rate. The effect of the TPE\u2010ss COF carrier is further elucidated by enhanced cardiomyocyte viability and triphenyltetrazolium chloride staining in vitro. This work demonstrates the cardioprotective effect of TPE\u2010ss COFs for MI\/R injury, which unleashes the immense potential of using COFs as smart drug carriers for the peri\u2010reperfusion treatment of ischemic heart disease with low cost, high stability, and single postoperative intervention.<\/jats:p>","DOI":"10.1002\/smll.202205062","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T13:56:23Z","timestamp":1666014983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Biodegradable Redox\u2010Responsive AIEgen\u2010Based\u2010Covalent Organic Framework Nanocarriers for Long\u2010Term Treatment of Myocardial Ischemia\/Reperfusion Injury"],"prefix":"10.1002","volume":"18","author":[{"given":"Chenguang","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Basic Medical Sciences Anhui Medical University  Hefei 230032 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