{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:38:24Z","timestamp":1790347104204,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160429"],"award-info":[{"award-number":["82160429"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972120"],"award-info":[{"award-number":["81972120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M690767"],"award-info":[{"award-number":["2021M690767"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n                    Noble metal nanozymes hold promise in cancer therapy due to adjustable enzyme\u2010like activities, unique physicochemical properties, etc. But catalytic activities of monometallic nanozyme are confined. In this study, 2D titanium carbide (Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    )\u2010supported RhRu alloy nanoclusters (RhRu\/Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    ) are prepared by a hydrothermal method and utilized for synergistic therapy of chemodynamic therapy (CDT), photodynamic therapy (PDT), and photothermal therapy (PTT) on osteosarcoma. The nanoclusters are small in size (3.6\u00a0nm), uniform in distribution, and have excellent catalase (CAT) and peroxidase (POD)\u2010like activities. Density functional theory calculations show that there is a significant electron transfer interaction between RhRu and Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    , which has strong adsorption to H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and is beneficial to enhance the enzyme\u2010like activity. Furthermore, RhRu\/Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    nanozyme acts as both PTT agent for converting light into heat, and photosensitizer for catalyzing O\n                    <jats:sub>2<\/jats:sub>\n                    to\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . With the NIR\u2010reinforced POD\u2010 and CAT\u2010like activity, excellent photothermal and photodynamic performance, the synergistic CDT\/PDT\/PTT effect of RhRu\/Ti\n                    <jats:sub>3<\/jats:sub>\n                    C\n                    <jats:sub>2<\/jats:sub>\n                    T\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    on osteosarcoma is verified by in vitro and in vivo experiments. This study is expected to provide a new research direction for the treatment of osteosarcoma and other tumors.\n                  <\/jats:p>","DOI":"10.1002\/smll.202205511","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T01:10:28Z","timestamp":1677978628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["RhRu Alloy\u2010Anchored MXene Nanozyme for Synergistic Osteosarcoma Therapy"],"prefix":"10.1002","volume":"19","author":[{"given":"Yanling","family":"Liang","sequence":"first","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. China"},{"name":"Life Sciences Institute Guangxi Medical University  Nanning Guangxi 530021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-0364","authenticated-orcid":false,"given":"Chuanan","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. China"},{"name":"Pharmaceutical College Guangxi Medical University  Nanning Guangxi 530021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. 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China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co\u2010constructed by the Province and Ministry The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. China"},{"name":"Life Sciences Institute Guangxi Medical University  Nanning Guangxi 530021 P. R. China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co\u2010constructed by the Province and Ministry The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine The First Affiliated Hospital of Guangxi Medical University  Nanning Nanning Guangxi 530021 P. R. China"},{"name":"School of Basic Medical Sciences Guangxi Medical University  Nanning Guangxi 530021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Life Sciences Institute Guangxi Medical University  Nanning Guangxi 530021 P. R. China"},{"name":"Guangxi Key Laboratory for High\u2010Incidence Tumor Prevention and Treatment Guangxi Medical University  Nanning Guangxi 530021 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi 530021 P. R. 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