{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:03:04Z","timestamp":1793307784915,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Multidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal\u2013phenolic network\u2010functionalized nanoparticles (t\u2010P@TFP NPs) are designed to realize multiple therapeutic modalities and reshape the TME from insensitive to sensitive under multimodal imaging monitoring. After a single irradiation, a near\u2010infrared laser\u2010activated multistage reaction occurs. t\u2010P@TFP NPs trigger the phase transition of perfluoropentane (PFP) to release tannic acid (TA)\/ferric ion (Fe\n                    <jats:sup>3+<\/jats:sup>\n                    )\u2010coated paclitaxel (PTX) and cause hyperthermia in the tumor region to efficiently kill cancer cells. Additionally, PTX is released after the disassembly of the TA\u2010Fe\n                    <jats:sup>3+<\/jats:sup>\n                    film by the abundant adenosine triphosphate (ATP) in the malignant tumor, which concurrently inhibits ATP\u2010dependent drug efflux to improve sensitivity to chemotherapeutic agents. Furthermore, hyperthermia\u2010induced immunogenic cell death (ICD) transforms \u201ccold\u201d tumors into \u201chot\u201d tumors with the assistance of PD\u20101\/PD\u2010L1 blockade to evoke antitumor immunogenicity. This work carefully reveals the mechanisms underlying the abilities of these multifunctional NPs, providing new insights into combating the proliferation and metastasis of multidrug\u2010resistant tumors.\n                  <\/jats:p>","DOI":"10.1002\/smll.202206174","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T03:44:38Z","timestamp":1674013478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["NIR Activated Multimodal Therapeutics Based on Metal\u2013Phenolic Networks\u2010Functionalized Nanoplatform for Combating against Multidrug Resistance and Metastasis"],"prefix":"10.1002","volume":"19","author":[{"given":"Chen","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Ultrasound and Chongqing Key Laboratory of Ultrasound Molecular Imaging the Second Affiliated Hospital of Chongqing Medical University  Chongqing 400010 P. R. 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