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The treatment of these injuries typically requires surgical operations for improving functional recovery of the nerve. However, capabilities for continuous nerve monitoring remain a challenge. Herein, a battery\u2010free, wireless, cuff\u2010type, implantable, multimodal physical sensing platform for continuous in vivo monitoring of temperature and strain from the injured nerve is introduced. The thin, soft temperature, and strain sensors wrapped around the nerve exhibit good sensitivity, excellent stability, high linearity, and minimum hysteresis in relevant ranges. In particular, the strain sensor integrated with circuits for temperature compensation provides reliable, accurate strain monitoring with negligible temperature dependence. The system enables power harvesting and data communication to wireless, multiple implanted devices wrapped around the nerve. Experimental evaluations, verified by numerical simulations, with animal tests, demonstrate the feasibility and stability of the sensor system, which has great potential for continuous in vivo nerve monitoring from an early stage to complete regeneration.<\/jats:p>","DOI":"10.1002\/smll.202206839","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T04:53:07Z","timestamp":1681793587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Battery\u2010Free, Wireless, Cuff\u2010Type, Multimodal Physical Sensor for Continuous Temperature and Strain Monitoring of Nerve"],"prefix":"10.1002","volume":"19","author":[{"given":"Seunghwan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering Korea Advanced Institute of Science and Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Suk","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Changwon National University  Changwon 51140 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanghyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Korea University College of Medicine  Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongchan","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Korea Institute of Science and Technology  Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo\u2010Youl","family":"Maeng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Su","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Korea University  Seoul 02841 Republic of Korea"},{"name":"Interdisciplinary Program in Precision Public Health Korea University  Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u2010Been","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Biomaterials Korea Institute of Science and Technology  Seoul 02841 Republic of Korea"},{"name":"School of Biomedical Engineering Korea University  Seoul 02841 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokjoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Korea Advanced Institute of Science and Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonseok","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Korea Advanced Institute of Science and Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunwoo","family":"Park","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering Korea Advanced Institute of Science and Technology  Daejeon 34141 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology  Dalian 116023 P. 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